Transient versus sustained visual channels in the visual backward masking deficits of schizophrenia patients
Transient versus sustained visual channels in the visual backward masking deficits of schizophrenia patients
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DOI：
10.1016/s0006-3223(97)00316-8
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发表时间：
1998-01-15
影响因子：
10.6
通讯作者：
Braff, DL
中科院分区：
文献类型：
--
作者：
Cadenhead, KS;Serper, Y;Braff, DL
背景：精神分裂症患者有信息处理缺陷，可以用视觉后向掩蔽来量化。视觉信息处理系统在功能和结构上分为瞬时视觉通道和持续视觉通道。当视觉刺激呈现给受试者时，瞬时通路检测刺激的存在和位置，而持续通路参与刺激的精细辨别和识别。虽然短暂和持续的视觉通道在皮层下是独立的，但它们在皮层下会聚到背侧和腹侧处理流中，分别评估空间关系和物体识别。为了更好地理解视觉后掩蔽缺陷的潜在机制，对16名精神分裂症患者和17名对照受试者进行了两种不同的视觉后向掩蔽范式的测试，目标字母。结果：精神分裂症患者有视觉后掩蔽缺陷的任务，涉及定位一个目标letter，而没有赤字的任务，涉及识别的目标letter.Conclusions：精神分裂症患者的视觉后掩蔽缺陷表明损害的空间信息的处理。这些缺陷的背景下，我们目前的知识的视觉信息处理和精神分裂症的神经病理生理学进行了讨论。(C)1998年生物精神病学学会。
Background: Schizophrenia patients have information-processing deficits that can be quantified using visual backward masking. The visual information processing system is divided functionally and structually into transient and sustained visual channels. When visual stimuli are presented to a subject, the transient pathway detects the presence and location of the stimulus while the sustained pathway is involved in fine discrimination and identification of the stimulus. While independent subcortically, the transient and sustained visual channels converge cortically into the dorsal and ventral processing streams that assess spatial relationships and object recognition respectively.Methods: To better understand the underlying mechanisms of the visual backward masking deficits, 16 schizophrenia patients and 17 comparison subjects were tested on two different visual backward masking paradigms that required either locating or identifying a target letter.Results: Schizophrenia patients had visual backward masking deficits in a task that involved locating a target letter while there were no deficits in the task that involved identification of a target letter.Conclusions: The visual backward masking deficits of schizophrenia patients suggest impairment in the processing of spatial information. These deficits are discussed in the context of our current knowledge of visual information processing and the neuropathophysiology of schizophrenia. (C) 1998 Society of Biological Psychiatry.