Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies.
Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies.
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DOI：
10.1161/jaha.113.000665
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发表时间：
2014-04-22
影响因子：
5.4
通讯作者：
Ky B
中科院分区：
文献类型：
--
作者：
Hahn VS;Lenihan DJ;Ky B
该患者是一名 63 岁男性，有控制良好的高血压病史，被诊断患有弥漫性大 B 细胞淋巴瘤，并接受含阿霉素的化疗方案治疗。在治疗期间，他继续服用氢氯噻嗪治疗高血压。三个月后，他主诉劳力呼吸困难和轻度下肢水肿。经胸超声心动图显示左心室射血分数（LVEF）适度降低，这与他接受化疗之前进行的研究相比是新的。
The patient is a 63-year-old man with a history of wellcontrolled hypertension who is diagnosed with diffuse large B-cell lymphoma and treated with a doxorubicincontaining chemotherapy regimen. During therapy, he is continued on hydrochlorothiazide for his hypertension. Three months later, he complains of dyspnea on exertion and mild lower extremity edema. A transthoracic echocardiogram reveals a moderately reduced left ventricular ejection fraction (LVEF), which is new compared with a study performed before he underwent chemotherapy.