Surgical strategies for colorectal liver metastases
Surgical strategies for colorectal liver metastases
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DOI：
10.1016/j.suronc.2004.08.001
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发表时间：
2004-08-01
影响因子：
2.3
通讯作者：
Poston, GJ
中科院分区：
文献类型：
--
作者：
Poston, GJ
在西方社会，结直肠癌仍然是癌症死亡的第二大常见原因。近一半的患者将发展为肝脏转移，许多人将死于仅限于肝脏的疾病。现在公认的可切除性的现代定义意味着，超过20%的患者现在是有治愈意图的可切除患者(手术死亡率为2%)，近三分之一的患者将在五年后存活，没有疾病。射频消融等其他技术的使用可能会给更多的患者带来长期生存的可能性。引入新的化疗方案，包括基于奥沙利铂的方案，可能会将三分之一的不可切除患者转变为具有治疗意图的可切除患者。因此，在2004年，近三分之一的仅限于肝脏疾病的患者现在可以期待有可能治愈的肝脏手术。(C)2004爱思唯尔有限公司。保留所有权利。
Colorectal cancer remains the second commonest cause of death from cancer in Western society. Nearly half of all patients will develop liver metastases and many will die with disease confined to the liver. The accepted modern definitions of resectability now mean that over twenty per cent of patients are now resectable (with operative mortality of >2%) with curative intent, and nearly one third will be alive, disease free, five years later. The use of additional techniques such as radiofrequency ablation may bring many more patients the possibility of long term survival. The introduction of new chemotherapy regimens, including those based on oxaliplatin may convert one third of non-resectable patients to resectability with curative intent. Therefore, in 2004 nearly one third of patients with disease confined to the liver can now look forward to possibly curative liver surgery. (C) 2004 Elsevier Ltd. All rights reserved.