Predictors of Blood Pressure Response to Angiotensin Receptor Blocker/Diuretic Combination Therapy: A Secondary Analysis of the Irbesartan/Hydrochlorothiazide Blood Pressure Reductions in Diverse Patient Populations (INCLUSIVE) Study
Predictors of Blood Pressure Response to Angiotensin Receptor Blocker/Diuretic Combination Therapy: A Secondary Analysis of the Irbesartan/Hydrochlorothiazide Blood Pressure Reductions in Diverse Patient Populations (INCLUSIVE) Study
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DOI：
10.1111/j.1524-6175.2007.07195.x
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Neutel, Joel
中科院分区：
文献类型：
--
作者：
Saunders, Elijah;Cable, Greg;Neutel, Joel
在不同患者人群中进行的厄贝沙坦/氢氯噻嗪降压（INCLUSIVE）临床试验的次要分析研究了基线人口统计学和临床变量是否可预测血管紧张素II受体阻滞剂/利尿剂治疗方案后不同程度的血压降低。已证明厄贝沙坦/氢氯噻嗪和其他血管紧张素受体阻滞剂与利尿剂的联合用药可有效降低既往单药治疗未控制的不同患者人群的收缩压。对INCLUSIVE研究的意向治疗人群进行普通最小二乘回归分析，以确定预测厄贝沙坦/氢氯噻嗪联合治疗后血压变化变异的变量。研究发现，较高的基线收缩压、女性、2型糖尿病和他汀类药物治疗可预测该联合治疗的额外血压降低。与男性患者相比，女性患者中较高的基线收缩压和糖尿病状态对收缩压变化的影响较小。总之，某些临床/人口统计学特征与厄贝沙坦/氢氯噻嗪治疗的治疗反应程度之间可能存在显著相关性。（J Clin Hypertens（格林威治）。2008年;10：27-33）（C）2008年Le Jacq
The secondary analysis of the Irbesartan/Hydrochlorothiazide Blood Pressure Reductions in Diverse Patient Populations (INCLUSIVE) clinical trial investigated whether baseline demographic and clinical variables are predictive of different degrees of blood pressure reduction following an angiotensin II receptor blocker/diuretic treatment regimen. Irbesartan/hydrochlorothiazide and other angiotensin receptor blocker combinations with a diuretic have been shown to be effective in reducing systolic blood pressure in a diverse patient population previously uncontrolled on monotherapy. Ordinary least squares regression analysis was Performed on the intent-to-treat population of the INCLUSIVE study to identify variables predictive of variations in blood pressure changes in response to irbesartan/hydrochlorothiazide combination therapy. Higher baseline systolic blood pressure, female sex, type 2 diabetes, and statin therapy were found to be predictive of additional blood pressure lowering with this combination. The impact of higher baseline systolic blood pressure and diabetic state on changes in systolic blood pressure were diminished in female patients compared with male patients. In conclusion, a significant correlation may exist between certain clinical/demographic characteristics and the extent of the therapeutic response with irbesartan/hydrochlorothiazide treatment. (J Clin Hypertens (Greenwich). 2008;10:27-33) (C)2008 Le Jacq