Atp11p and Atp12p are chaperones for F1-ATPase biogenesis in mitochondria
Atp11p and Atp12p are chaperones for F1-ATPase biogenesis in mitochondria
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DOI：
10.1016/s0005-2728(02)00262-1
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发表时间：
2002-09-10
影响因子：
4.3
通讯作者：
Ackerman, SH
中科院分区：
文献类型：
--
作者：
Ackerman, SH
有氧细胞的生物能量需求主要通过F1F0ATP合成酶的作用来满足，F1F0ATP合成酶在氧化磷酸化过程中催化ATP合成。酶的催化单元(F-1)是亚基组成为α(3)β(3)Gammadeltaepsilon的多聚体蛋白。我们的工作使用酿酒酵母作为研究线粒体功能的模型系统，提供了证据表明，将线粒体α和β亚基组装成F-1寡聚体需要两个分子伴侣蛋白Atp11p和Atp12p。对线粒体中Atp11p和Atp12p活性的全面了解与人类生理和疾病相关，因为这些伴侣作用现在已知存在于人类细胞的线粒体中。(C)2002 Elsevier Science B.V.保留所有权利。
The bioenergetic needs of aerobic cells are met principally through the action of the F1F0 ATP synthase, which catalyzes ATP synthesis during oxidative phosphorylation. The catalytic unit of the enzyme (F-1) is a multimeric protein of the subunit composition alpha(3)beta(3)gammadeltaepsilon. Our work, which employs the yeast Saccharomyces cerevisiae as a model system for studies of mitochondrial function, has provided evidence that assembly of the mitochondrial alpha and beta subunits into the F-1 oligomer requires two molecular chaperone proteins called Atp11p and Atp12p. Comprehensive knowledge of Atp11p and Atp12p activities in mitochondria bears relevance to human physiology and disease as these chaperone actions are now known to exist in mitochondria of human cells. (C) 2002 Elsevier Science B.V. All rights reserved.