Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors

Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors
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DOI：
10.1016/j.tripleo.2011.05.033
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发表时间：
2011-10-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
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通讯作者：
Freitas, Roseana de Almeida
Freitas, Roseana de Almeida
中科院分区：
其他
文献类型：
--
作者：
Gomes Henriques, Aguida Cristina;Vasconcelos, Marcelo Gadelha;Freitas, Roseana de Almeida

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Objective.本研究的目的是评估含牙囊肿（DC）、根尖囊肿（RC）、角化囊性牙源性肿瘤（KOT）和成釉细胞瘤中IV型胶原、基质金属蛋白酶（MMP）9和MMP组织抑制剂（TIMP）2的免疫组化表达。选取20例DCs、20例RCs、20例KOT和20例成釉细胞瘤进行免疫组化分析。大多数DC和RC在上皮基底膜中显示出连续且> 50%的IV型胶原染色，而主要是不连续的薄且
Objective. The aim of this study was to evaluate the immunohistochemical expression of collagen IV, matrix metalloproteinase (MMP) 9 and tissue inhibitor of MMP (TIMP) 2 in dentigerous cysts (DCs), radicular cysts (RCs), keratocystic odontogenic tumors (KOTs), and ameloblastomas.Study design. Twenty cases of DCs, 20 RCs, 20 KOTs, and 20 ameloblastomas were selected and analyzed by immunohistochemistry.Results. Most DCs and RCs showed continuous and > 50% staining for collagen IV in the basement membrane of the epithelium, whereas predominantly discontinuous thin and