Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N-Acyl Propiolamides.
Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N-Acyl Propiolamides.
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DOI：
10.1021/acs.orglett.8b03068
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发表时间：
2018-10
期刊：
影响因子：
5.2
通讯作者：
Yan He;Ying-Chun Wang;Xinping Liang;Bin Huang;Hengshan Wang;Ying‐Ming Pan
中科院分区：
文献类型：
--
作者：
Yan He;Ying-Chun Wang;Xinping Liang;Bin Huang;Hengshan Wang;Ying‐Ming Pan
钯催化的末端炔烃、异腈和羧酸钠之间的三组分反应已经被开发出来。这种新颖且操作简单的方法为在温和的条件下合成N-酰基丙醇胺衍生物提供了一种替代方法，该方法以异腈为胺源，以羧酸钠为氧源和酰基来源。
Palladium-catalyzed three-component reactions between terminal alkynes, isonitriles, and sodium carboxylates have been developed. This novel and operationally simple methodology provides an alternative for the synthesis of N-acyl propiolamide derivatives under mild conditions using isonitriles as the amine source and sodium carboxylates as the oxygen and acyl source.