Epigenomics and allergic disease.
Epigenomics and allergic disease.
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DOI：
10.2217/epi.13.68
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发表时间：
2013-12
期刊：
影响因子：
3.8
通讯作者：
Karmaus W
中科院分区：
文献类型：
--
作者：
Lockett GA;Patil VK;Soto-Ramírez N;Ziyab AH;Holloway JW;Karmaus W
过敏性疾病的发展受到基因和环境的影响，并且假设表观遗传机制介导这些环境效应。在这篇文章中，我们讨论了环境，DNA甲基化和过敏性疾病之间的联系，以及DNA甲基化分析固有的因果关系问题。从实践的角度，我们描述了过敏表型的特点，并对比了表观遗传学研究中使用的不同流行病学研究设计。我们研究了方法上的考虑，如何最好地进行DNA甲基化数据集的预处理和分析，以及在这个快速发展的领域中的最新方法，技术和发现。DNA甲基化和其他表观遗传标记与过敏性疾病密切相关，这一联系可能为未来过敏性疾病的诊断和治疗奠定基础。
Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment.