Comparison of stage IV and IV-S neuroblastoma in the first year of life.
Comparison of stage IV and IV-S neuroblastoma in the first year of life.
复制标题
IV 期和 IV-S 期神经母细胞瘤在生命第一年的比较。
DOI：
10.1002/mpo.2950130504
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Hammond,D
中科院分区：
文献类型：
--
作者：
Nickerson,HJ;Nesbit,ME;Grosfeld,JL;Baehner,RL;Sather,H;Hammond,D
在1972年至1979年在儿童癌症研究组（CCSG）机构观察的44例IV-S期和44例IV期神经母细胞瘤患者（年龄0至12个月）中评价了临床分期和与生存相关的因素。在73例完成手术分期的患者中，生命表预测的3年生存率为91%（IV-S期）和44%（IV期）。IV‐S期疾病的唯一死亡发生在诊断时年龄小于2个月的3名患者中。在诊断时3至12个月的IV‐S期，无病生存率为97%。化疗或放疗似乎没有提高IV-S期的生存率。这些研究进一步证明了IV期和IV-S期神经母细胞瘤患者之间的显著临床和生物学差异，并表明他们需要不同的治疗管理。
Clinical staging and factors related to survival were evaluated in 44 stage IV‐S and 44 stage IV patients with neuroblastoma, ages 0 to 12 months, seen at Childrens Cancer Study Group (CCSG) institutions from 1972 to 1979. In 73 patients with complete surgical staging, the life‐table projected survival at 3 years was 91% for stage IV‐S and 44% for stage IV. The only deaths in stage IV‐S disease occurred in three patients less than 2 months old at diagnosis. In stage IV‐S, 3 to 12 months old at diagnosis, the disease‐free survival was 97%. Chemotherapy or radiation therapy did not appear to improve the survival rate in stage IV‐S.These studies further document a significant clinical and biologic difference between patients with stage IV and stage IV‐S neuroblastoma and suggest that they require different therapeutic management.