Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory
Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory
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DOI：
10.1128/mcb.25.10.4166-4175.2005
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发表时间：
2005-05-01
影响因子：
5.3
通讯作者：
Miyajima, A
中科院分区：
文献类型：
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作者：
Bando, T;Sekine, K;Miyajima, A
神经元亮氨酸重复序列蛋白（Neuronal leucine-rich repeat protein, nlrr）是一类跨膜蛋白，在神经组织中表达，但其功能尚不清楚。在这里，我们描述了NLRR家族新成员NLRR4的鉴定和特征，以及它在持久记忆中的潜在作用。我们产生了NLRR4缺陷（NLRR4(-/-)）小鼠，发现它们表现出记忆保留受损。在海马体依赖性学习任务中，NLRR4（-/-）小鼠能够学习并维持一天的记忆，但在学习后无法保留四天的记忆。相比之下，在海马体独立任务中，NLRR4（-/-）小鼠能够正常保留记忆至少7天。这些结果表明NLRR4在海马体依赖性持久记忆中起关键作用。
Neuronal leucine-rich repeat proteins (NLRRs) are type I transmembrane proteins and expressed in neuronal tissues, but their function remains unknown. Here, we describe the identification and characterization of a new member of the NLRR family, NLRR4, and its potential role in long-lasting memory. We generated NLRR4-deficient (NLRR4(-/-)) mice and found that they showed impaired memory retention. In hippocampus-dependent learning tasks, NLRR4(-/-) mice were able to learn and maintain the memories for one day but unable to retain the memories for four days after learning. In contrast, in a hippocampus-independent task, NLRR4(-/-) mice were able to retain the memory normally for at least seven days. These results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory.