The variable heart: High frequency and very low frequency correlates of depressive symptoms in children and adolescents.
The variable heart: High frequency and very low frequency correlates of depressive symptoms in children and adolescents.
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DOI：
10.1016/j.jad.2015.06.057
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发表时间：
2015-11-01
影响因子：
6.6
通讯作者：
Crowley MJ
中科院分区：
文献类型：
--
作者：
Blood JD;Wu J;Chaplin TM;Hommer R;Vazquez L;Rutherford HJ;Mayes LC;Crowley MJ
研究儿童和青少年较低心率变异性（HRV）与抑郁症之间联系的工作缺乏，特别是考虑到青春期发育期间发生的生理变化。我们调查了127名年龄在10-17岁的儿童和青少年的静息心率变异性频谱测量值与抑郁症状之间的关系。使用频谱分析，我们评估了（1）相对高频（HF）HRV与抑郁症状之间的关联;（2）相对低频（LF）和相对极低频（VLF）HRV背景下相对HF HRV对抑郁症状的预测能力;（3）相对HF、LF和VLF频带活动、年龄和青春期成熟之间的关系。与以前的工作一致，结果显示，相对HF HRV与自我报告的抑郁症状呈负相关。同时，相对VLF HRV与抑郁症状呈正相关。回归分析显示，相对HF HRV和相对VLF HRV显着预测自我报告的抑郁症状，同时控制年龄，性别和青春期成熟，与相对VLF HRV出现的抑郁症状的最强指标。发展的结果也出现了。年龄和青春期成熟度与相对HF HRV呈负相关，与相对VLF HRV呈正相关。结果支持HRV与抑郁症之间的关系，并表明HF和VLF HRV与抑郁症症状的严重程度有关。研究结果还加强了在调查儿童和青少年的HRV抑郁协会时考虑青春期发育的重要性。在未来的工作中，可以控制对心脏控制的影响，包括体力活动水平和运动模式。我们的数据说话抑郁症状的尺寸和相对频谱功率HRV。因此，我们不能对相对频谱功率HRV和临床抑郁症做出强有力的声明。
Work examining the link between lower heart rate variability (HRV) and depression in children and adolescents is lacking, especially in light of the physiological changes that occur during pubertal development. We investigated the association between spectral measures of resting HRV and depressive symptoms among 127 children and adolescents, ages 10–17. Using spectral analysis, we evaluated (1) the association between relative high frequency (HF) HRV and depressive symptoms; (2) the predictive power of relative HF HRV for depressive symptoms in the context of relative low frequency (LF) and relative very low frequency (VLF) HRV; and (3) the relationship between relative HF, LF, and VLF band activity, age and pubertal maturation. Consistent with previous work, results revealed that relative HF HRV was negatively associated with self-reported depressive symptoms. As well, relative VLF HRV was positively associated with depressive symptoms. Regression analyses revealed that relative HF HRV and relative VLF HRV significantly predicted self-report depressive symptoms while controlling for age, sex and pubertal maturation, with relative VLF HRV emerging as the strongest indicator of depressive symptoms. Developmental findings also emerged. Age and pubertal maturation were negatively associated with relative HF HRV and positively correlated with relative VLF HRV. Results provide support for the relationship between HRV and depression and suggest that both HF and VLF HRV are relevant to depression symptom severity. Findings also reinforce the importance of considering pubertal development when investigating HRV-depression associations in children and adolescents. Influences on cardiac control including physical activity levels and exercise patterns could be controlled in future work. Our data speak to a depressive symptom dimension and relative spectral power HRV. Thus, we cannot make strong claims about relative spectral power HRV and clinical depression.