Association of adiponectin with coronary heart disease and mortality - The Rancho Bernardo Study
Association of adiponectin with coronary heart disease and mortality - The Rancho Bernardo Study
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DOI：
10.1093/aje/kwk001
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发表时间：
2007-01-15
影响因子：
5
通讯作者：
Langenberg, Claudia
中科院分区：
文献类型：
--
作者：
Laughlin, Gail A.;Barrett-Connor, Elizabeth;Langenberg, Claudia
低脂联素血症与肥胖相关疾病的发生有关，包括血脂异常和冠心病 (CHD)。在这项研究中，作者对 1,513 名年龄在 50-91 岁的社区居住男性和女性进行了 1984-1987 年至 2004 年跟踪调查，研究了脂联素与 CHD 患病率、发病率和死亡率的关系。在横断面分析中，脂联素浓度与女性性别、年龄和高密度脂蛋白胆固醇水平呈正相关，与腰围、甘油三酯呈负相关。水平和空腹血糖水平（所有 p < 0.001）。与性别最低的五分位数相比，脂联素水平最高的五分位数与冠心病患病率降低 44% 相关（趋势 p = 0.03）；对高密度脂蛋白胆固醇和/或甘油三酯的调整消除了这种关联。在 20 年的前瞻性分析中，较高的脂联素浓度仅预测男性非致命性心肌梗死的风险降低；无论男女，脂联素与致命性 CHD 事件或 20 年 CHD 死亡率（n = 215 例死亡）均无关。与较低水平相比，最高性别特异性五分之一的脂联素水平与心血管疾病死亡 (n = 441) 和全因死亡 (n = 925) 的风险增加近 40% 相关，与年龄、性别、腰围、血脂水平和血糖水平无关（均 p < 0.001）。这些结果表明，使用脂联素进行心血管疾病风险分层还为时过早。
Hypoadiponectinemia has been implicated in the development of obesity-related conditions, including dyslipidemia and coronary heart disease (CHD). In this study, the authors examined the association of adiponectin with CHD prevalence, incidence, and mortality among 1,513 community-dwelling men and women aged 50-91 years who were followed from 1984-1987 through 2004. In cross-sectional analyses, adiponectin concentrations were positively related to female sex, age, and high density lipoprotein cholesterol level and inversely related to waist girth, triglyceride level, and fasting plasma glucose level (all p's < 0.001). Adiponectin levels in the highest sex-specific quintile, as compared with the lowest, were associated with 44% decreased odds of prevalent CHD (p for trend = 0.03); adjustment for high density lipoprotein cholesterol and/or triglycerides eliminated this association. In 20-year prospective analyses, higher adiponectin concentrations predicted reduced risk of nonfatal myocardial infarction in men only; adiponectin was not associated with fatal incident CHD events or 20-year CHD mortality (n = 215 deaths) in either sex. Adiponectin levels in the highest sex-specific quintile, as compared with lower levels, were associated with almost 40% increased risks of cardiovascular disease death (n = 441) and death from all causes (n = 925), independent of age, sex, waist girth, lipid levels, and glucose level (both p's < 0.001). These results suggest that use of adiponectin for cardiovascular disease risk stratification is premature.