The epidemiology and global burden of autism spectrum disorders
The epidemiology and global burden of autism spectrum disorders
复制标题
DOI：
10.1017/s003329171400172x
复制
发表时间：
2015-02-01
影响因子：
6.9
通讯作者：
Scott, J. G.
中科院分区：
文献类型：
--
作者：
Baxter, A. J.;Brugha, T. S.;Scott, J. G.
背景自闭症谱系障碍（ASD）是从儿童早期临床上明显的持续性致残性神经发育障碍。2010年全球疾病负担研究（GBD 2010）首次估计了ASD的负担。本研究的目的是开发全球和区域患病率模型，并估计ASD的全球疾病负担。对孤独症和其他ASD的流行病学资料（患病率、发病率、缓解率和死亡风险）进行系统评价。使用贝叶斯元回归方法合并数据，同时调整研究间方差以获得患病率模型。负担的计算方法是残疾生存年数（YLD）和残疾调整生命年数（DLDs），这里按世界地区报告1990年和2010年的数据。2010年，估计有5200万例ASD病例，相当于每1000人中有7.6例或每132人中有1例患病。在考虑了方法的差异后，没有明确的证据表明1990年至2010年期间自闭症或其他ASD的患病率发生了变化。在世界范围内，ASD的患病率几乎没有地区差异。在全球范围内，自闭症占每10万人中超过58例，其他ASD占每10万人中53例。ASD在整个生命周期中造成了大量的健康损失。了解ASD的负担对于有效的政策制定至关重要。需要对ASD进行准确的流行病学描述，以告知公共卫生政策并规划教育，住房和财政支持服务。
Background. Autism spectrum disorders (ASDs) are persistent disabling neurodevelopmental disorders clinically evident from early childhood. For the first time, the burden of ASDs has been estimated for the Global Burden of Disease Study 2010 (GBD 2010). The aims of this study were to develop global and regional prevalence models and estimate the global burden of disease of ASDs.Method. A systematic review was conducted for epidemiological data (prevalence, incidence, remission and mortality risk) of autistic disorder and other ASDs. Data were pooled using a Bayesian meta-regression approach while adjusting for between-study variance to derive prevalence models. Burden was calculated in terms of years lived with disability (YLDs) and disability-adjusted life-years (DALYs), which are reported here by world region for 1990 and 2010.Results. In 2010 there were an estimated 52 million cases of ASDs, equating to a prevalence of 7.6 per 1000 or one in 132 persons. After accounting for methodological variations, there was no clear evidence of a change in prevalence for autistic disorder or other ASDs between 1990 and 2010. Worldwide, there was little regional variation in the prevalence of ASDs. Globally, autistic disorders accounted for more than 58 DALYs per 100000 population and other ASDs accounted for 53 DALYs per 100000.Conclusions. ASDs account for substantial health loss across the lifespan. Understanding the burden of ASDs is essential for effective policy making. An accurate epidemiological description of ASDs is needed to inform public health policy and to plan for education, housing and financial support services.