What We Should Know Before Using Tissue Engineering Techniques to Repair Injured Tendons: A Developmental Biology Perspective
What We Should Know Before Using Tissue Engineering Techniques to Repair Injured Tendons: A Developmental Biology Perspective
复制标题
DOI：
10.1089/ten.teb.2010.0662
复制
发表时间：
2011-06-01
影响因子：
6.4
通讯作者：
Wylie, Christopher
中科院分区：
文献类型：
--
作者：
Liu, Chia-Feng;Aschbacher-Smith, Lindsey;Wylie, Christopher
肌腱将肌肉连接到骨骼，并作为力的传递器，允许身体的所有运动。腱细胞是肌腱的基本细胞单位，并产生形成肌腱的分级纤维系统的胶原蛋白。肌腱损伤是常见的，并且难以修复，特别是在肌腱插入骨的情况下。基于细胞的修复疗法的成功尝试将需要理解肌腱组织的正常发育，包括它们的分化区域，例如纤维中段和纤维软骨插入部位。已知许多基因参与肌腱的形成。然而，它们在肌腱发育中的功能作用尚未得到充分表征。组织工程师试图在体外产生功能性肌腱组织。然而，缺乏正常肌腱发育的知识阻碍了这些努力。在这里，我们审查的研究重点是肌腱发育的发育机制，并讨论了肌腱发育的分子理解治疗肌腱损伤的潜在应用。
Tendons connect muscles to bones, and serve as the transmitters of force that allow all the movements of the body. Tenocytes are the basic cellular units of tendons, and produce the collagens that form the hierarchical fiber system of the tendon. Tendon injuries are common, and difficult to repair, particularly in the case of the insertion of tendon into bone. Successful attempts at cell-based repair therapies will require an understanding of the normal development of tendon tissues, including their differentiated regions such as the fibrous mid-section and fibrocartilaginous insertion site. Many genes are known to be involved in the formation of tendon. However, their functional roles in tendon development have not been fully characterized. Tissue engineers have attempted to generate functional tendon tissue in vitro. However, a lack of knowledge of normal tendon development has hampered these efforts. Here we review studies focusing on the developmental mechanisms of tendon development, and discuss the potential applications of a molecular understanding of tendon development to the treatment of tendon injuries.