Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress
Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress
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DOI：
10.1073/pnas.160260697
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发表时间：
2000-08-01
影响因子：
11.1
通讯作者：
Jackowski, S
中科院分区：
文献类型：
--
作者：
Attard, GS;Templer, RH;Jackowski, S
CTP：磷酸胆碱胞苷转移酶是磷脂酰胆碱生物合成的限速酶，其活性受其与脂双分子层相互作用的调节[Kent，C.(1997)Biochim，BiPhys，Acta 1348，79-90]。它的调节在维持膜脂的动态平衡中起着重要的作用，我们的证据表明，脂质膜单层中储存的曲率弹性应力调节了CTP：磷酸胆碱胞苷转移酶的活性。我们的结果表明，一个纯粹的物理反馈信号如何在膜脂合成的控制中发挥关键作用。
The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.