Regulation of Microsomal HMG-CoA Reductase by Enzyme-Lipid Interactions.
Regulation of Microsomal HMG-CoA Reductase by Enzyme-Lipid Interactions.
复制标题
酶-脂质相互作用对微粒体 HMG-CoA 还原酶的调节。
DOI：
10.1016/s0006-3495(82)84589-x
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发表时间：
1982
影响因子：
3.4
通讯作者：
R. Thompson
中科院分区：
文献类型：
--
作者：
V. L. Smith;L. G. Brent;M. S. Shabbot;R. Thompson
总之，这些结果表明腺苷酸环化酶具有催化活性的特定磷脂需求。改变酶的脂质环境很可能是一种机制，通过激素、细胞代谢状态的变化或在分化过程中正常调节酶的活性。存在许多可能的机制来影响酶的脂质环境的变化。例如，通过磷脂交换蛋白将抑制性脂质交换为刺激性脂质或水解磷脂酰胆碱以产生溶血磷脂酰胆碱两者都可以被预测为激活腺苷酸环化酶。目前正在调查这些和其他可能性。
In conclusion, these results suggest adenylate cyclase has a specific phospholipid requirement for catalytic activity. Changing the lipid environment of the enzyme might well be a mechanism whereby activity is normally modu-lated by hormones, by changes in the metabolic status of the cell, or during differentiation. Many possible mecha-nisms exist for effecting changes in the lipid environment of the enzyme. For example, exchanging an inhibitory for a stimulatory lipid by a phospholipid exchange protein or hydrolyzing phosphatidylcholine to produce lysophosphatidylcholine can both be predicted to activate adenylate cyclase. These and other possibilities are currently under investigation.