NK Cell Inflammation in the Clinical Outcome of Colorectal Carcinoma.
NK Cell Inflammation in the Clinical Outcome of Colorectal Carcinoma.
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DOI：
10.3389/fmed.2015.00033
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发表时间：
2015
影响因子：
3.9
通讯作者：
Sconocchia G
中科院分区：
文献类型：
--
作者：
Coppola A;Arriga R;Lauro D;Del Principe MI;Buccisano F;Maurillo L;Palomba P;Venditti A;Sconocchia G
自然杀伤（NK）细胞提供针对骨髓性白血病的保护的能力已在临床环境中得到证实。然而，NK细胞是否在实体瘤的临床过程中发挥作用仍存在争议。围绕NK细胞作用的争议至少部分是由于在肿瘤床中发现的NK细胞浸润的有限程度。NK细胞的失活可以解释结直肠癌（CRC）微环境中NK细胞的缺乏。在NK细胞/肿瘤细胞相互作用后，肿瘤细胞可以通过产生免疫抑制微环境来逃避NK细胞，这也可能影响T细胞。这种免疫抑制微环境会阻碍NK和T细胞的功能，并减少NK和T细胞的相互作用。已经鉴定了具有适于统计分析的肿瘤NK细胞浸润水平的CRC患者。NK细胞与CD 8 + T淋巴细胞结合对CRC微环境的浸润已被证明可增强CRC患者的预后。在这里，我们讨论了NK细胞在CRC中的临床病理学作用，并提供了临床数据，表明NK细胞在CD 8 + T细胞的抗CRC作用中具有潜在的支持作用。
The ability of natural killer (NK) cells to provide protection against myeloid leukemia has been demonstrated in clinical settings. However, whether NK cells play a role in the clinical course of solid tumors is debated. The controversy surrounding the role of NK cells is due, at least in part, to the limited extent of NK cell infiltration found in the tumor bed. Inactivation of NK cells may explain the shortage of NK cells in the microenvironment of colorectal cancer (CRC). Upon NK cell/tumor cell interaction, tumor cells may escape NK cells by creating an immunosuppressive microenvironment, which possibly affects T-cells as well. Such an immunosuppressive microenvironment would hamper the functions of NK and T-cell and reduce NK and T-cell interactions. CRC patients with levels of tumor NK cell infiltration suitable for statistical analysis have been identified. The infiltration of the CRC microenvironment by NK cells, in combination with CD8+ T-lymphocytes, has been shown to enhance the prognosis of CRC patients. Here, we discuss the clinicopathological role of NK cells in CRC, and present clinical data indicating a potential supporting role for NK cells in the anti-CRC effects of CD8+ T-cells.