DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers.
DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers.
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DOI：
10.3802/jgo.2015.26.1.40
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发表时间：
2015-01
影响因子：
3.9
通讯作者：
Furuya K
中科院分区：
文献类型：
--
作者：
Kato M;Takano M;Miyamoto M;Sasaki N;Goto T;Tsuda H;Furuya K
近年来研究发现DNA错配修复（MMR）基因突变与子宫内膜癌的发生密切相关，但MMR蛋白表达对预后的影响尚不明确。本研究旨在分析子宫内膜癌组织中MMP-2相关蛋白表达与临床病理因素的关系。共纳入1990年至2007年在我院治疗的191例子宫内膜癌组织。对组织芯片标本和临床病理特征的MSH 2、MLH 1、MSH 6和PMS 2的免疫反应进行回顾性分析。76例（40%）患者至少有一种MMR蛋白的免疫组化改变（MMR缺陷组）。MMR缺失组与MMR保留组在组织学、国际妇产科联盟（FIGO）分期、组织学分级等方面差异有统计学意义。在可评价病例中，MMR缺陷病例的一线化疗缓解率略高（67% vs. 44%，p=0.34）。与保留MMR的病例相比，MMR缺陷病例的无进展生存期和总生存期（OS）明显更好。多变量分析显示，MMR状态是子宫内膜癌OS的独立预后因素。MMR相关蛋白表达被确定为OS的独立预后因素，这表明MMR是进一步研究子宫内膜癌的关键生物标志物。
Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not determined. Correlations between MMR-related protein expression and clinicopathological factors of endometrial cancers are analyzed in the present study. A total of 191 endometrial cancer tissues treated between 1990 and 2007 in our hospital were enrolled. Immunoreactions for MSH2, MLH1, MSH6, and PMS2 on tissue microarray specimens and clinicopathological features were analyzed retrospectively. Seventy-six cases (40%) had at least one immunohistochemical alteration in MMR proteins (MMR-deficient group). There were statistically significant differences of histology, International Federation of Gynecology and Obstetrics (FIGO) stage, and histological grade between MMR-deficient group and the other cases (MMR-retained group). Response rate of first-line chemotherapy in evaluable cases was slightly higher in MMR-deficient cases (67% vs. 44%, p=0.34). MMR-deficient cases had significantly better progression-free and overall survival (OS) compared with MMR-retained cases. Multivariate analysis revealed MMR status was an independent prognostic factor for OS in endometrial cancers. MMR-related proteins expression was identified as an independent prognostic factor for OS, suggesting that MMR was a key biomarker for further investigations of endometrial cancers.
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影响因子：
4.7
作者：
Grzankowski, Kassondra S.;Shimizu, David M.;Terada, Keith Y.
通讯作者：
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影响因子：
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作者：
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作者：
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作者：
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