Recreational physical activity and endometrial cancer risk
Recreational physical activity and endometrial cancer risk
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DOI：
10.1093/aje/154.10.924
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发表时间：
2001-11-15
影响因子：
5
通讯作者：
Weiss, NS
中科院分区：
文献类型：
--
作者：
Littman, AJ;Voigt, LF;Weiss, NS
为了调查娱乐性体力活动与子宫内膜癌风险之间的关系，在华盛顿州进行了一项基于人群的病例对照研究。该研究包括1985年至1991年诊断的822例子宫内膜癌病例和1，111例随机选择的基于人群的对照。娱乐性体育活动以及其他子宫内膜癌危险因素的详细信息是在结构化的面对面访谈中获得的。采用非条件logistic回归分析，调整年龄、县、能量摄入、无对抗性雌激素使用、收入，以及在不同模型中调整体重指数（kg/m2），以估计子宫内膜癌与每种体力活动水平的比值比及其95%置信区间。在诊断日期之前的2年内，对照组（49.3%）比病例组（40.5%）更大比例的患者报告进行定期锻炼（与不锻炼相比：调整后的比值比= 0.62，95%置信区间：0.51，0.76）。几乎没有证据表明，随着娱乐性体育活动的持续时间或强度的增加，风险呈下降趋势。这些结果为最近缺乏娱乐性体力活动与子宫内膜癌风险之间的关联提供了支持。然而，持续时间或强度水平的差异以及其他研究的不一致结果表明，在将这种关联解释为因果关系之前应谨慎。
To investigate the association between recreational physical activity and endometrial cancer risk, a population-based case-control study was conducted in Washington State. The study included 822 incident cases of endometrial cancer diagnosed between 1985 and 1991 and 1,111 randomly selected population-based controls. Detailed information on recreational physical activities as well as other endometrial cancer risk factors was obtained in structured, in-person interviews. Unconditional logistic regression, adjusted for age, county, energy intake, unopposed estrogen use, income, and, in separate models, body mass index (kg/m(2)), was used to estimate the odds ratios and their 95% confidence intervals, relating endometrial cancer to each level of physical activity. A greater proportion of controls (49.3%) than cases (40.5%) reported doing regular exercise (compared with no exercise: adjusted odds ratio = 0.62, 95% confidence interval: 0.51, 0.76) in the 2-year period prior to diagnosis date. There was little evidence of a trend of decreasing risk with increasing duration or intensity of recreational physical activities. These results provide support for an association between the lack of recent recreational physical activity and endometrial cancer risk. However, the absence of a difference by duration or intensity levels and the inconsistent results from other studies suggest caution before interpreting this association as causal.