New insights into therapeutic activity and anticancer properties of curcumin.
New insights into therapeutic activity and anticancer properties of curcumin.
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DOI：
10.2147/jep.s70568
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发表时间：
2017
影响因子：
--
通讯作者：
Sa G
中科院分区：
文献类型：
--
作者：
Panda AK;Chakraborty D;Sarkar I;Khan T;Sa G
从植物中获得的天然化合物能够获得科学界的相当大的关注，主要是由于它们能够检查和预防癌症的发生和发展。这些天然化合物主要是由于它们的无毒性质和与化疗药物相比它们引起的副作用较少而使用的。此外，当与传统化疗药物一起作为佐剂沿着给予时，这样的天然产物表现甚至更好，从而增强化疗药物的潜力并同时减少它们不希望的副作用。姜黄素是一种天然存在的多酚化合物，存在于植物姜黄中，被用作印度香料。它不仅调节免疫系统的各种途径、细胞周期检查点、细胞凋亡和抗氧化反应，而且调节许多细胞内靶点，包括控制肿瘤进展的途径和蛋白质分子。由地球仪周围的主要研究小组进行的许多最近的研究表明，使用姜黄素作为化学预防佐剂分子，以最大化和最小化化疗药物的期望效果和副作用。然而，姜黄素分子的低生物利用度是辅助治疗中遇到的主要挑战。这篇综述探讨了姜黄素的不同治疗相互作用沿着靶向通路和分子，这些通路和分子参与调节不同类型癌症的发作和进展，癌症治疗，以及克服生物利用度问题的策略和姜黄素在不断增长的癌症领域的新靶点。
Natural compounds obtained from plants are capable of garnering considerable attention from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer. These natural compounds are primarily used due to their nontoxic nature and the fewer side effects they cause compared to chemotherapeutic drugs. Furthermore, such natural products perform even better when given as an adjuvant along with traditional chemotherapeutic drugs, thereby enhancing the potential of chemotherapeutics and simultaneously reducing their undesired side effects. Curcumin, a naturally occurring polyphenol compound found in the plant Curcuma longa, is used as an Indian spice. It regulates not only the various pathways of the immune system, cell cycle checkpoints, apoptosis, and antioxidant response but also numerous intracellular targets, including pathways and protein molecules controlling tumor progression. Many recent studies conducted by major research groups around the globe suggest the use of curcumin as a chemopreventive adjuvant molecule to maximize and minimize the desired effects and side effects of chemotherapeutic drugs. However, low bioavailability of a curcumin molecule is the primary challenge encountered in adjuvant therapy. This review explores different therapeutic interactions of curcumin along with its targeted pathways and molecules that are involved in the regulation of onset and progression of different types of cancers, cancer treatment, and the strategies to overcome bioavailability issues and new targets of curcumin in the ever-growing field of cancer.