Antiaggressive activity of central oxytocin in male rats
Antiaggressive activity of central oxytocin in male rats
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DOI：
10.1007/s00213-013-3124-7
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发表时间：
2013-10-01
影响因子：
3.4
通讯作者：
Koolhaas, Jaap M.
中科院分区：
文献类型：
--
作者：
Calcagnoli, Federica;de Boer, Sietse F.;Koolhaas, Jaap M.
大量研究表明，神经肽催产素促进包括人类在内的各种动物的社会亲和行为。然而，它的抗攻击作用还没有在雄性实验室啮齿动物中得到明确的证实。我们的主要目标是在野生动物中检测催产素的假定的serenic效应（野生型格罗宁根，WTG）的大鼠，通常表现出更广泛的变化和更高水平的雄性间的攻击比常用的实验室品系的大鼠。用不同剂量的合成催产素和催产素受体拮抗剂单独和联合给药，以操纵脑催产素功能并评估它们对入侵者的行为反应。我们的数据清楚地表明，急性icv给药的催产素在社会行为中产生剂量依赖性和受体选择性的变化，减少攻击性和加强社会探索。这些反攻击性的作用在攻击性更强的老鼠身上更强。另一方面，催产素受体拮抗剂的管理往往会增加（不显着）侵略只有在低-中等aggressiveanimals.These结果表明，短暂增强脑催产素功能有强大的抗侵略性的影响，而其衰减往往会增强侵略性。此外，性状侵略和内源性催产素信号之间可能存在负相关关系。总的来说，这项研究强调了脑催产素能信号调节雄性间攻击性攻击的重要性。这项研究支持了催产素受体激动剂在临床上可用于抑制一系列神经精神疾病（如反社会人格障碍，自闭症和成瘾）中的攻击性增强的建议。
A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents.Our primary goal was to examine the putative serenic effect of oxytocin in a feral strain (wild type Groningen, WTG) of rats that generally show a much broader variation and higher levels of intermale aggression than commonly used laboratory strains of rats.Resident animals were intracerebroventricularly (icv) administered with different doses of synthetic oxytocin and oxytocin receptor antagonist, alone and in combination, in order to manipulate brain oxytocin functioning and to assess their behavioral response to an intruder.Our data clearly demonstrate that acute icv administered oxytocin produces dose-dependent and receptor-selective changes in social behavior, reducing aggression and potentiating social exploration. These antiaggressive effects are stronger in the more offensive rats. On the other hand, administration of an oxytocin receptor antagonist tends to increase (nonsignificantly) aggression only in low-medium aggressive animals.These results suggest that transiently enhancing brain oxytocin function has potent antiaggressive effects, whereas its attenuation tends to enhance aggressiveness. In addition, a possible inverse relationship between trait aggression and endogenous oxytocinergic signaling is revealed. Overall, this study emphasizes the importance of brain oxytocinergic signaling for regulating intermale offensive aggression. This study supports the suggestion that oxytocin receptor agonists could clinically be useful for curbing heightened aggression seen in a range of neuropsychiatric disorders like antisocial personality disorder, autism, and addiction.