Statin-associated myasthenia gravis - Report of 4 cases and review of the literature
Statin-associated myasthenia gravis - Report of 4 cases and review of the literature
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DOI：
10.1097/01.md.0000209337.59874.aa
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发表时间：
2006-03-01
期刊：
影响因子：
1.6
通讯作者：
Kesler, A
中科院分区：
文献类型：
--
作者：
Purvin, V;Kawasaki, A;Kesler, A
最近的一些个案报告表明肌无力综合征可能与他汀类药物治疗有关，但这种关联尚未得到很好的描述。我们报告了 4 名患者在开始使用他汀类药物治疗后 2 周内出现重症肌无力症状。在 1 例中，该药物似乎加剧了潜在的肌无力，而在其他 3 例中，似乎最有可能是从头形成抗体。在每种情况下，停止使用他汀类药物后，患者都会得到一定程度的恢复。
A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described. We report 4 patients who developed symptoms of myasthenia gravis within 2 weeks of starting treatment with a statin drug. In 1 case the drug appears to have exacerbated underlying myasthenic weakness, whereas in the other 3 cases, de novo antibody formation appears to be most likely. In each case, some degree of recovery followed discontinuation of the statin medication.