Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits.
Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits.
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DOI：
10.3746/pnf.2014.19.2.059
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发表时间：
2014-06
影响因子：
--
通讯作者：
Jeong YS
中科院分区：
文献类型：
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作者：
Nyakudya E;Jeong JH;Lee NK;Jeong YS
桔梗根的提取物和纯皂苷具有广泛的保健功效。来自PG根的Platycosides（皂苷）的特征在于含有三萜苷元和两个糖链的结构。皂苷具有商业意义，并且它们的应用随着它们的健康益处的越来越多的证据而增加。皂苷的生物学作用包括对癌细胞的细胞毒性作用、神经保护活性、抗病毒活性和降低胆固醇作用。具有商业价值的皂苷的范围从可用于其发泡性质的粗植物提取物到可用于其健康应用（例如，作为疫苗佐剂）。这项综述表明，桔梗总苷具有许多健康益处，并有可能用作对抗许多主要健康危害的药物（例如，癌症、肥胖症、阿尔茨海默氏症）。本文还对桔梗皂苷的分离纯化和分析方法进行了综述。
The extracts and pure saponins from the roots of Platycodon grandiflorum (PG) are reported to have a wide range of health benefits. Platycosides (saponins) from the roots of PG are characterized by a structure containing a triterpenoid aglycone and two sugar chains. Saponins are of commercial significance, and their applications are increasing with increasing evidence of their health benefits. The biological effects of saponins include cytotoxic effects against cancer cells, neuroprotective activity, antiviral activity, and cholesterol lowering effects. Saponins with commercial value range from crude plant extracts, which can be used for their foaming properties, to high purity saponins such as platycodin D, which can be used for its health applications (e.g., as a vaccine adjuvant). This review reveals that platycosides have many health benefits and have the potential to be used as a remedy against many of the major health hazards (e.g., cancer, obesity, alzheimer’s) faced by populations around the world. Methods of platycoside purification and analysis are also covered in this review.