Three Cases of Intravascular Large B-Cell Lymphoma Detected in a Biopsy of Skin Lesions
Three Cases of Intravascular Large B-Cell Lymphoma Detected in a Biopsy of Skin Lesions
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DOI：
10.1159/000437363
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发表时间：
2016-01-01
期刊：
影响因子：
3.4
通讯作者：
Tsuboi, Ryoji
中科院分区：
文献类型：
--
作者：
Arai, Takashi;Kato, Yukihiko;Tsuboi, Ryoji
血管内大b细胞淋巴瘤（IVL）是结外恶性淋巴瘤中一种罕见的亚型。肿瘤B细胞在小血管内的增殖引起各种器官的爆发和其他症状。随机皮肤活检在早期诊断这种疾病是有用的。为了评估该方法的诊断效用，我们检查了3例患者，目的是通过对32个不同部位进行随机皮肤活检，比较病变皮肤和健康皮肤中肿瘤细胞的发生。我们从3例患者的32个活检标本中发现，病变皮肤的17个部位中有16个肿瘤细胞阳性，而健康皮肤的15个部位中有1个肿瘤细胞阳性。这一发现表明，IVL细胞在病变皮肤中比在看起来健康的皮肤中更频繁地发生。(C) 2016 S. Karger AG，巴塞尔
Intravascular large B-cell lymphoma (IVL) is a rare subtype of extranodal malignant lymphoma. The proliferation of neoplastic B cells within small blood vessels causes eruptions and other symptoms in a variety of organs. The random skin biopsy is useful for diagnosing this condition in its early stages. In order to assess the diagnostic utility of this method, we examined 3 cases with the aim of comparing the occurrence of tumor cells in lesional and healthy-looking skin by performing a random skin biopsy of 32 separate sites. Our findings from the total of 32 biopsy specimens collected from the 3 cases indicated that 16 of the 17 sites on the lesional skin and 1 of the 15 sites on the healthy-looking skin were positive for neoplastic cells. This finding suggested that IVL cells occurred more frequently in the lesional skin than in the healthy-looking skin. (C) 2016 S. Karger AG, Basel