Inhibition of knee joint sensory afferents alters covariation across strides between quadriceps muscles during locomotion
Inhibition of knee joint sensory afferents alters covariation across strides between quadriceps muscles during locomotion
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DOI：
10.1152/japplphysiol.00591.2022
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发表时间：
2023-04-01
影响因子：
3.3
通讯作者：
Tresch，Matthew C.
中科院分区：
文献类型：
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作者：
Alessandro，Cristiano;Prashara，Adarsh;Tresch，Matthew C.
与运动相关的关节结构损伤通常会改变关节结构向神经系统传递的感觉信息。然而，关节感觉传入在运动控制中的作用仍不清楚。在这里，我们评估膝关节感觉传入在股四头肌控制中的作用，假设这种感觉信息调节限制髌股关节负荷的控制策略。我们比较了通过向大鼠膝关节囊注射利多卡因抑制膝关节感觉传入之前和之后的运动运动学和肌肉活动。我们评估了这种抑制是否降低了股内侧肌（VM）和股外侧肌（VL）的活动之间的相关性强度，无论是在跨步还是在每个跨步内，限制净内侧髌股力的协调模式。我们还评估了这种抑制是否改变了其他股四头肌活动、个体肌电图包络的时间分布或运动运动学之间的相关性。肌电图包络和肢体运动学都不受膝部感觉传入抑制的影响。这种扰动也没有影响 VM 和 VL 之间的相关性，表明髌股关节负荷的调节是由不同的机制介导的。然而，膝部感觉传入的抑制导致股中间肌 (VI) 与跨步幅 (而非步幅内) 的 VM 和 VL 之间的相关性显着降低。因此，膝关节感觉传入可能会调节股阔肌之间的协调，但仅限于粗略的时间尺度。损害关节传入神经的损伤可能会导致肌肉协调性改变，从而可能导致持续的内部关节压力和拉伤。新的和值得注意的来自膝关节受体的感觉传入神经系统提供有关关节内部状态的信息。在这项研究中，我们表明这些感觉信号用于调节股阔肌子集跨运动步幅的活动之间的协变。因此，损害关节感受器的运动相关损伤可能会损害这些肌肉协调机制，可能导致持续的内部关节压力和拉伤。
Sport-related injuries to articular structures often alter the sensory information conveyed by joint structures to the nervous system. However, the role of joint sensory afferents in motor control is still unclear. Here, we evaluate the role of knee joint sensory afferents in the control of quadriceps muscles, hypothesizing that such sensory information modulates control strategies that limit patellofemoreal joint loading. We compared locomotor kinematics and muscle activity before and after inhibition of knee sensory afferents by injection of lidocaine into the knee capsule of rats. We evaluated whether this inhibition reduced the strength of correlation between the activity of vastus medialis (VM) and vastus lateralis (VL) both across strides and within each stride, coordination patterns that limit net mediolateral patellofemoral forces. We also evaluated whether this inhibition altered correlations among the other quadriceps muscle activity, the time-profiles of individual EMG envelopes, or movement kinematics. Neither the EMG envelopes nor limb kinematics was affected by the inhibition of knee sensory afferents. This perturbation also did not affect the correlations between VM and VL, suggesting that the regulation of patellofemoral joint loading is mediated by different mechanisms. However, inhibition of knee sensory afferents caused a significant reduction in the correlation between vastus intermedius (VI) and both VM and VL across, but not within, strides. Knee joint sensory afferents may therefore modulate the coordination between the vasti muscles but only at coarse time scales. Injuries compromising joint afferents might result in altered muscle coordination, potentially leading to persistent internal joint stresses and strains.NEW & NOTEWORTHYSensory afferents originating from knee joint receptors provide the nervous system with information about the internal state of the joint. In this study, we show that these sensory signals are used to modulate the covariations among the activity of a subset of vasti muscles across strides of locomotion. Sport-related injuries that damage joint receptors may therefore compromise these mechanisms of muscle coordination, potentially leading to persistent internal joint stresses and strains.