Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents
Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents
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DOI：
10.1038/ijo.2017.14
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发表时间：
2017-05-01
影响因子：
4.9
通讯作者：
Yoon, K-H
中科院分区：
文献类型：
--
作者：
Kang, B.;Yang, Y.;Yoon, K-H
目的：我们的目的是调查甘油三酯/葡萄糖指数（TyG指数）和稳态模型评估估计的胰岛素抵抗（HOMA-IR）之间的关联，在青少年胰岛素抵抗（IR）的预测方法：我们进行了一项横断面研究，221名韩国青少年（168名男性和53名女性，年龄9-13岁）从2014年5月至6月在忠州市。TyG指数计算为ln [甘油三酯（mg dl（-1））x空腹血糖（mg dl（-1））/ 2]。结果：IR组的体重、体重指数（BMI）、腰围、体脂、空腹胰岛素、空腹血糖、甘油三酯水平及甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）均显著高于非IR组。IR组（n = 22）和非IR组（n = 199）的TG指数分别为8.43 +/- 0.45和8.05 +/- 0.41，差异有统计学意义（P < 0.001）。TyG指数与HOMA-IR呈显著正相关（r = 0.41; P < 0.001），与TG/HDL-C呈显著正相关（r = 0.84; P < 0.001）。TyG指数诊断胰岛素抵抗的临界值为8.18。结论：与HOMA-IR相比，TyG指数是一种简便、经济的青少年胰岛素抵抗替代指标。
OBJECTIVES: Our aim was to investigate the association between the triglycerides/glucose index (TyG index) and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) in the prediction of insulin resistance (IR) among adolescents.METHODS: We conducted a cross-sectional study among 221 Korean adolescents (168 males and 53 females aged 9-13 years) from May to June 2014 in Chung-ju city. The TyG index was calculated as ln [triglycerides (mg dl(-1)) x fasting glucose (mg dl(-1))/ 2]. IR was defined using HOMA-IR 495th percentile for age and sex.RESULTS: In the IR group, weight, body mass index (BMI), waist circumference, body fat, fasting insulin, fasting plasma glucose, triglyceride levels and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) were significantly higher than that in the non-IR group. The TG index was significantly different between the IR group (n = 22) and non-IR group (n = 199), at 8.43 +/- 0.45 and 8.05 +/- 0.41, respectively (P < 0.001). The TyG index was well correlated with HOMA-IR (r = 0.41; P < 0.001) and showed a strong positive association with TG/HDL-C (r = 0.84; P < 0.001). The cut-off of the TyG index for diagnosis of insulin resistance was 8.18.CONCLUSIONS: The TyG index is a simple, cost-effective surrogate marker of insulin resistance among adolescents compared with HOMA-IR.