The Roles of Left Versus Right Anterior Temporal Lobes in Conceptual Knowledge: An ALE Meta-analysis of 97 Functional Neuroimaging Studies.
The Roles of Left Versus Right Anterior Temporal Lobes in Conceptual Knowledge: An ALE Meta-analysis of 97 Functional Neuroimaging Studies.
复制标题
DOI：
10.1093/cercor/bhv024
复制
发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Hoffman P
中科院分区：
文献类型：
--
作者：
Rice GE;Lambon Ralph MA;Hoffman P
左右前颞叶在概念知识中的作用是4种相互矛盾的解释之间争论的一个来源。可能的ATL专业化包括：（1）处理语言与非语言输入;（2）涉及单词检索;（3）刺激的社会内容。相反，“轴辐”理论认为两个ATL形成了一个双边功能统一的系统。使用激活似然估计（ALE）比较左和右ATL激活的概率，我们分析了97个功能性神经影像学研究的概念知识，根据三个专门的假设的预测。主要的结果是，ATL激活主要是双边和高度重叠的所有刺激类型。除了这种双边代表性之外，ATL之间和内部都有微妙的等级。当输入是一个书面单词或需要单词检索时，激活更有可能被偏侧化。这些数据是最好的容纳分级版本的轴辐帐户，从而表示概念知识的支持，通过双边但分级连接之间的ATL和各种特定模态的感觉，运动，和边缘皮层。
The roles of the right and left anterior temporal lobes (ATLs) in conceptual knowledge are a source of debate between 4 conflicting accounts. Possible ATL specializations include: (1) Processing of verbal versus non-verbal inputs; (2) the involvement of word retrieval; and (3) the social content of the stimuli. Conversely, the “hub-and-spoke” account holds that both ATLs form a bilateral functionally unified system. Using activation likelihood estimation (ALE) to compare the probability of left and right ATL activation, we analyzed 97 functional neuroimaging studies of conceptual knowledge, organized according to the predictions of the three specialized hypotheses. The primary result was that ATL activation was predominately bilateral and highly overlapping for all stimulus types. Secondary to this bilateral representation, there were subtle gradations both between and within the ATLs. Activations were more likely to be left lateralized when the input was a written word or when word retrieval was required. These data are best accommodated by a graded version of the hub-and-spoke account, whereby representation of conceptual knowledge is supported through bilateral yet graded connectivity between the ATLs and various modality-specific sensory, motor, and limbic cortices.