Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics.
Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics.
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DOI：
10.1039/c5sc01733e
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发表时间：
2015-10-01
期刊：
影响因子：
8.4
通讯作者：
Liu B
中科院分区：
文献类型：
--
作者：
Xu S;Yuan Y;Cai X;Zhang CJ;Hu F;Liang J;Zhang G;Zhang D;Liu B
系统间交叉过程的效率可以通过减小单态和三态激发态之间的能量差(ΔE ST)来提高，这为提高三态激发态的产额提供了机会。系统间交叉过程的效率可以通过减小单态和三态激发态之间的能量差(ΔE ST)来提高，这为提高三态激发态的产额提供了机会。在这里，我们证明了激发态的调制也是调节光敏剂单线态氧产生的一种有效策略。基于我们以前的研究，具有聚集诱导发射特征的光敏剂具有增强的荧光和有效的聚集态产生单线态氧的特性，我们合成了一系列聚集诱导发射特征光敏剂，其ΔE-ST值分别为0.48、0.35和0.27 eV。一项详细的研究表明，PPDC作为纳米聚集体表现出最高的单线态氧效率(0.89)，而TPDC表现出最低的效率(0.28)，与它们的ΔE-ST值成反比。由于其相似的光学性质，TPDC和PPDC进一步被包裹到纳米粒子(NPs)中。随后用细胞穿透肽(TAT)进行表面修饰，得到TAT-TPDC纳米颗粒和TAT-PPDC纳米颗粒。与TAT-TPDC纳米粒相比，TAT-PPDC纳米粒显示出更强的单线态氧生成，从而增强了癌细胞的消融作用。因此，微调单重态-三重态能隙被证明是一种有效的新策略，可以产生用于光动力治疗的高效光敏剂。
The efficiency of the intersystem crossing process can be improved by reducing the energy gap between the singlet and triplet excited states (ΔE ST), which offers the opportunity to improve the yield of the triplet excited state. The efficiency of the intersystem crossing process can be improved by reducing the energy gap between the singlet and triplet excited states (ΔE ST), which offers the opportunity to improve the yield of the triplet excited state. Herein, we demonstrate that modulation of the excited states is also an effective strategy to regulate the singlet oxygen generation of photosensitizers. Based on our previous studies that photosensitizers with aggregation-induced emission characteristics (AIE) showed enhanced fluorescence and efficient singlet oxygen production in the aggregated state, a series of AIE fluorogens such as TPDC, TPPDC and PPDC were synthesized, which showed ΔE ST values of 0.48, 0.35 and 0.27 eV, respectively. A detailed study revealed that PPDC exhibited the highest singlet oxygen efficiency (0.89) as nanoaggregates, while TPDC exhibited the lowest efficiency (0.28), inversely correlated with their ΔE ST values. Due to their similar optical properties, TPDC and PPDC were further encapsulated into nanoparticles (NPs). Subsequent surface modification with cell penetrating peptide (TAT) yielded TAT–TPDC NPs and TAT–PPDC NPs. As a result of the stronger singlet oxygen generation, TAT–PPDC NPs showed enhanced cancer cell ablation as compared to TAT–TPDC NPs. Fine-tuning of the singlet-triplet energy gap is thus proven to be an effective new strategy to generate efficient photosensitizers for photodynamic therapy.
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影响因子：
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作者：
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