Association of Serum Lipocalin-Type Prostaglandin D Synthase Levels with Subclinical Atherosclerosis in Untreated Asymptomatic Subjects
Association of Serum Lipocalin-Type Prostaglandin D Synthase Levels with Subclinical Atherosclerosis in Untreated Asymptomatic Subjects
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DOI：
10.1291/hypres.31.1931
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发表时间：
2008-10-01
影响因子：
5.4
通讯作者：
Sasaguri, Tsohiyuki
中科院分区：
文献类型：
--
作者：
Miwa, Yoshikazu;Oda, Hiroshi;Sasaguri, Tsohiyuki
最近的研究表明，将前列腺素H(2)转化为前列腺素D(2)的Lipocalin型前列腺素(PG)D合成酶(L-PGDS)与动脉粥样硬化的发生有关。然而，关于血清L-前列腺素DS水平与动脉粥样硬化之间关系的临床证据尚未见报道。本研究采用双抗体夹心酶联免疫吸附试验检测500例无症状者血清L-前列腺素D_2水平，并探讨其与传统心血管危险因素和替代动脉粥样硬化指标如颈动脉内中膜复合体最大厚度(C-IMT(Max))和臂踝脉搏波速度(ba-PWV)的关系。血清L-PGDS浓度为0.56+/-0.01(扫描电子显微镜范围0.25-1.27，中位数0.54)mg/L。血清L-PGDS水平随年龄增长而升高，男性高于女性。高血压病患者血清L-PGDS水平较高，且随传统动脉粥样硬化危险因素增多而升高。将受试者按血清L-PGDS水平分为4组时，无论男女，L-PGDS水平较高者(四分位数3和四分位数4)的年龄调整后C-IMT(Max)和ba-Pwv均显著高于最低四分位数(四分位数1)。包括危险因素在内的多元回归分析显示，血清L-前列腺素D是影响ba-PWV的独立决定因素(β=0.130，p<；0.001)。血清L-PGDS水平与C-IMTmax呈正相关，但无统计学意义(β=0.084，p=0.075)。综上所述，我们的结果提示，血清L-前列腺素DS浓度的升高与动脉粥样硬化的进展有关。(Hyperten Res 2008；31：1931-1939)
Recent studies suggest that lipocalin-type prostaglandin (PG) D synthase (L-PGDS), which converts PGH(2) to PGD(2), is implicated in the pathogenesis of atherosclerosis. However, clinical evidence for the association between serum L-PGDS levels and atherosclerosis has not been reported. In this study, we measured the serum L-PGDS concentration using sandwich enzyme-linked immunosorbent assay (ELISA) and investigated the association with traditional cardiovascular risk factors and surrogate atherosclerotic indices, such as the maximum score of the intima-media complex thickness of the carotid artery (C-IMT(max)) and the brachial-ankle pulse wave velocity (ba-PWV), in 500 non-treated asymptomatic subjects. The serum concentration of L-PGDS was 0.56 +/- 0.01 (mean SEM, range 0.25-1.27, median 0.54) mg/L. Serum L-PGDS levels increased with age and were higher in men than in women. Serum L-PGDS was higher in subjects with hypertension and increased with increasing numbers of the traditional atherosclerotic risk factors. When the subjects were divided into four groups according to the levels of serum L-PGDS, the age-adjusted values of C-IMT(max) and ba-PWV were significantly increased in subjects with higher serum L-PGDS levels (quartile 3 and quartile 4) compared to those in the lowest quartile (quartile 1), for both genders. Multiple regression analysis including risk factors revealed that serum L-PGDS was an independent determinant for ba-PWV (beta=0.130, p < 0.001). Serum L-PGDS tended to associate with C-IMTmax but was not statistically significant (beta=0.084, p=0.075). In conclusion, our results suggest that an increase in serum L-PGDS concentration is associated with the progression of atherosclerosis. (Hypertens Res 2008; 31: 1931-1939)