Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis
Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis
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DOI：
10.1182/blood.v89.11.4100
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发表时间：
1997-06-01
期刊：
影响因子：
20.3
通讯作者：
Tawa, A
中科院分区：
文献类型：
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作者：
Osugi, Y;Hara, J;Tawa, A
噬血细胞性淋巴组织细胞增生症（HLH）是由T细胞和巨噬细胞过度活化引起的。与这种疾病相关的临床特征是由于Th 1细胞因子包括干扰素-γ（IFN-γ）、白细胞介素-2（IL-2）和肿瘤坏死因子-α（TNF-α）的过度产生。在这项研究中，我们分析了IL-12和IL-4的产生，分别决定Th 1和Th 2反应，IL-10，拮抗Th 1细胞因子，在11例HLH患者。在所有患者的血浆中检测到IL-12（平均峰值，30.0 +/- 5.0 pg/mL），而在9名患者中大量产生IFN-γ（平均峰值，79.2 +/- 112.0 U/mL）。在所有患者中均未检测到IL-4。所有患者的血浆IL-10水平均升高（平均峰值，2，698.0 +/-3，535.0 pg/mL）。IFN-γ与IL-10水平呈正相关（P <0.01）。这些细胞因子的血浆浓度最初很高，在急性期后降低。然而，IL-10水平的下降比IFN-γ的下降慢。虽然IL-12的浓度在急性期很高，但在一些患者中，水平的峰值延迟到慢性期。因此，在HLH中，促进Th 1细胞发育的细胞因子的产生似乎比促进Th 2细胞发育的细胞因子的产生占主导地位。还观察到IL-10的过度产生，表明在患有这种疾病的患者中抑制Th 1细胞和单核细胞/巨噬细胞功能过度活化的机制。(C)1997年，美国血液学会。
Hemophagocytic lymphohistiocytosis (HLH) is caused by the hyperactivation of T cells and macrophages. The clinical characteristics associated with this disease result from overproduction of Th1 cytokines including interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-alpha). In this study, we analyzed the production of IL-12 and IL-4, which determine Th1 and Th2 response, respectively, and IL-10, which antagonizes Th1 cytokines, in 11 patients with HLH. IL-12 was detected in plasma in all patients (mean peak value, 30.0 +/- 5.0 pg/mL), while IFN-gamma was massively produced in nine patients (mean peak value, 79.2 +/- 112.0 U/mL). IL-4 was not detected in any of the patients. Plasma IL-10 levels were elevated in ail patients (mean peak value, 2,698.0 +/- 3,535.0 pg/mL). There was a positive correlation between the levels of IFN-gamma and IL-10 (P < .01). The plasma concentrations of these cytokines were initially high, before decreasing after the acute phase. However, the decrease in IL-10 levels was slower than that of IFN-gamma. Although the concentration of IL-12 was high at the acute phase, in some patients, a peak in the level was delayed until the chronic phase. Thus, in HLH, production of cytokines that promote development of Th1 cells appears to be predominant over that for Th2 cell development. Overproduction of IL-10 was also observed indicating that a mechanism suppressing hyperactivation of Th1 cells and monocytes/macrophages functions in patients with this disease. (C) 1997 by The American Society of Hematology.