Pain Anticipation: An Activation Likelihood Estimation Meta-Analysis of Brain Imaging Studies
Pain Anticipation: An Activation Likelihood Estimation Meta-Analysis of Brain Imaging Studies
复制标题
DOI：
10.1002/hbm.22727
复制
发表时间：
2015-05-01
影响因子：
4.8
通讯作者：
Amanzio, Martina
中科院分区：
文献类型：
--
作者：
Palermo, Sara;Benedetti, Fabrizio;Amanzio, Martina
疼痛的预期已经在各种脑成像研究中进行了研究。重要的是，今天还没有明确的整体图片的领域，涉及不同的研究和确切的作用，这些地区在疼痛的预期仍然是特别未开发。为了解决这个问题，我们使用激活可能性估计荟萃分析来分析几项神经影像学研究中的疼痛预期。共有19个功能性磁共振成像被纳入分析，以寻找人类实验模型中参与疼痛预期的皮质区。在预期过程中，激活灶位于背外侧前额叶、扣带回中部和前额叶皮质、额内侧回和额下回、顶下小叶、颞中回和颞上级回、丘脑和尾状核。失活灶位于扣带回前部、上级额回、海马旁回和屏状核。元分析连接性分析的结果提供了一个由预期有害刺激引发的大脑反应的整体视图。这种高度分布的感知自我调节可能会激发大脑区域处理信息，其中情感、动作和感知及其相关子类别发挥核心作用。这些发现不仅提供了关于预期疼痛时神经事件的重要信息，而且它们还可以透视反安慰剂反应，即负面预期可能导致疼痛恶化。《脑地图》36：1648-1661，2015年。(c)2014年威利期刊公司
The anticipation of pain has been investigated in a variety of brain imaging studies. Importantly, today there is no clear overall picture of the areas that are involved in different studies and the exact role of these regions in pain expectation remains especially unexploited. To address this issue, we used activation likelihood estimation meta-analysis to analyze pain anticipation in several neuroimaging studies. A total of 19 functional magnetic resonance imaging were included in the analysis to search for the cortical areas involved in pain anticipation in human experimental models. During anticipation, activated foci were found in the dorsolateral prefrontal, midcingulate and anterior insula cortices, medial and inferior frontal gyri, inferior parietal lobule, middle and superior temporal gyrus, thalamus, and caudate. Deactivated foci were found in the anterior cingulate, superior frontal gyrus, parahippocampal gyrus and in the claustrum. The results of the meta-analytic connectivity analysis provide an overall view of the brain responses triggered by the anticipation of a noxious stimulus. Such a highly distributed perceptual set of self-regulation may prime brain regions to process information where emotion, action and perception as well as their related subcategories play a central role. Not only do these findings provide important information on the neural events when anticipating pain, but also they may give a perspective into nocebo responses, whereby negative expectations may lead to pain worsening. Hum Brain Mapp 36:1648-1661, 2015. (c) 2014 Wiley Periodicals, Inc.