Does the presentation of Creutzfeldt-Jakob disease vary by age or presumed etiology? A meta analysis of the past 10 years
Does the presentation of Creutzfeldt-Jakob disease vary by age or presumed etiology? A meta analysis of the past 10 years
复制标题
DOI：
10.1176/appi.neuropsych.19.4.428
复制
发表时间：
2007-09-01
影响因子：
2.9
通讯作者：
Rabins, Peter V.
中科院分区：
文献类型：
--
作者：
Appleby, Brian S.;Appleby, Kristin K.;Rabins, Peter V.
目前尚不清楚克雅氏病的症状表现是否因年龄或病因亚型而异。使用关键词“Creutzfeldt-Jakob”进行PubMed检索，并按英语对过去10年的结果进行排序。我们发现，某些特征，如情感性疾病（28.8%），在年轻患者中更常见，无论疾病类型如何。年轻的发病年龄预示着出现情感性疾病、睡眠障碍和注意力不集中的症状，以及某些神经系统症状，包括小脑/步态障碍、视觉/眼科障碍、感觉障碍、眩晕/头晕和头痛。
It is not clear whether differences in symptom presentation vary by age or etiological subtype in Creutzfeldt-Jakob disease. A PubMed search was conducted using the keyword "Creutzfeldt-Jakob" and results within the last 10 years were sorted by the English language. We found that certain characteristics, such as affective illness (28.8%), present more commonly in younger patients irrespective of disease type. Young age of onset predicts presenting symptoms of affective illness, sleep disturbance, and poor concentration, as well as certain neurological symptoms, including cerebellar/gait disturbance, visual/oculomotor disturbance, sensory disorder, vertigo/dizziness, and headache.