Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes.
Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes.
复制标题
用含羞草碱增强缺氧诱导因子 1α 的药理作用可增强吞噬细胞的杀菌能力。
DOI：
10.1086/524843
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Nizet,Victor
中科院分区：
文献类型：
--
作者：
Zinkernagel,AnneliesS;Peyssonnaux,Carole;Johnson,RandallS;Nizet,Victor
缺氧诱导因子（HIF）-1α在接触细菌病原体时被激活并调节吞噬细胞的先天免疫功能。我们发现HIF-1α激动剂含羞草碱可以剂量依赖性地增强人吞噬细胞和全血杀死主要病原体金黄色葡萄球菌的能力，并减少S.金黄色皮肤感染这为通过增强宿主吞噬细胞功能来治疗细菌感染的新方法提供了原理的第一个证据。
Hypoxia-inducible factor (HIF)—1α is activated on exposure to bacterial pathogens and regulates the innate immune functions of phagocytes. We show here that the HIF-1α agonist mimosine can boost the capacity of human phagocytes and whole blood to kill the leading pathogenStaphylococcus aureusin a dose-dependent fashion and reduce the lesion size in a murine model ofS. aureusskin infection. This provides the first proof of principle for a novel approach to the treatment of bacterial infection by pharmacologically augmenting the host phagocytic cell function.