Effects of baroreceptor denervation on endocrine and drinking responses to caval constriction in dogs.
Effects of baroreceptor denervation on endocrine and drinking responses to caval constriction in dogs.
复制标题
压力感受器去神经对犬的内分泌和饮水反应对腔静脉收缩的影响。
DOI：
10.1152/ajpregu.1990.259.3.r618
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Reid,IA
中科院分区：
文献类型：
--
作者：
QuillenJr,EW;Keil,LC;Reid,IA
胸下腔静脉缩窄(TIVCC)可增加血浆精氨酸加压素(AVP)、血浆肾素活性(PRA)和水摄入量(H_2OIN)。为探讨心脏和窦-主动脉压力感受器在上述反应中的作用，对9只假手术犬、10只心(CD)犬、6只窦主动脉(SAD)犬和4只心-窦-主动脉(CD+SAD)联合去神经清醒犬进行了研究。所有动物都被研究在1)不能接触水(H2O-)和2)允许饮用(H2O+)的情况下进行研究。TIVCC对所有患者的平均动脉压(-32+/-4毫米汞柱)、左房压(-6.5+/-1.1cmH2O)和右房压(-4.2cmH2O+/-0.8cmH2O)的影响相似(P<0.001)。假手术组AVP由3.6pg/ml升至72.8pg/ml(P<0.001)。AVP与SAD相似(57.1+/-6.9)，但CD(30.9+/-3.0)和CD+SAD(17.7+/-4.0)降低。血浆血管紧张素Ⅱ从14.0±2.8pg/ml升至59.5±13.0pg/ml(P<0.001)。各组血浆促肾上腺皮质激素(ACTH)升高相似(55+/-5至128+/-25pg/ml)。血浆去甲肾上腺素(NE)水平在所有组中都有类似的升高(298+/-61至654+/-88 pg/ml)。
Plasma arginine vasopressin (AVP), plasma renin activity (PRA), and water intake (H2OIN) are increased by thoracic inferior vena caval constriction (TIVCC). To assess the role of the cardiac and sinoaortic baroreceptors in these responses, 9 sham-, 10 cardiac-(CD), 6 sinoaortic-(SAD), and 4 combined cardiac and sinoaortic-(CD + SAD) denervated conscious dogs were studied. All animals were studied while normally hydrated 1) with no access to water (H2O-) and 2) while drinking was permitted (H2O+). TIVCC caused similar reductions (P less than 0.001) of mean arterial (-32 +/- 4 mmHg), left atrial pressure (-6.5 +/- 1.1 cmH2O), and right atrial pressure (-4.2 +/- 0.8 cmH2O) in all groups. After TIVCC in sham dogs with H2O-, AVP increased from 3.6 +/- 0.7 to 72.8 +/- 12.6 pg/ml (P less than 0.001). AVP was similar with SAD (57.1 +/- 6.9) but was reduced with CD (30.9 +/- 3.0) and CD + SAD (17.7 +/- 4.0). In all groups, PRA increased from 4.5 +/- 0.7 to 23.8 +/- 3.0 ng.ml-1 x 3 h-1 and plasma angiotensin II (ANG II) increased from 14.0 +/- 2.8 to 59.5 +/- 13.0 pg/ml (P less than 0.001). Plasma adrenocorticotropic hormone (ACTH) increased similarly in all groups (55 +/- 5 to 128 +/- 25 pg/ml). Plasma norepinephrine (NE) levels increased similarly in all groups (298 +/- 61 to 654 +/- 88 pg/ml).(ABSTRACT TRUNCATED AT 250 WORDS)