Gamma synuclein: Subcellular localization in neuronal and non-neuronal cells and effect on signal transduction
Gamma synuclein: Subcellular localization in neuronal and non-neuronal cells and effect on signal transduction
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DOI：
10.1002/cm.1035
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发表时间：
2001-08-01
影响因子：
--
通讯作者：
Surgucheva, I
中科院分区：
文献类型：
--
作者：
Surguchov, A;Palazzo, RE;Surgucheva, I
Synucleins are small, highly conserved proteins in vertebrates. especially abundant in neurons and typically enriched in presynaptic terminals. alpha -Synuclein protein and a fragment of it, called NAC, have been found in association with pathological lesions of neurodegenerative diseases. Recently. mutations in a alpha -synuclein gene have been reported in families susceptible to an inherited form of Parkinson's diseases. In addition. alpha -synuclein has been implicated in the pathophysiology of other neurodegenerative diseases, including Alzheimer's disease and multiple system atrophy. Far less is known about other members of the synuclein family, beta- and gamma -synucleins. gamma -synuclein is up-regulated in several types of cancer and may affect the integrity of the neurofilament network. while its bovine ortholog. synoretin, activates the Elk-1 signal transduction pathway. In this paper. we present data about the localization and properties of human and bovine gamma -synuclein in several neuronal and non-neuronal cell cultures derived from ocular tissues. We show that gamma -synuclein is present in the perinuclear area and is localized to centrosomes in several types of human interphase cells and in bovine retinal pigment epithelium. In mitotic cells, gamma -synuclein staining is localized to the poles of the spindle. Further. overexpression of synoretin in retinoblastoma cells up-regulates MAPK and Elk-1. These results support the view that gamma -synuclein is a centrosome protein that may be involved in signal transduction pathways. Cell Motil. Cytoskeleton 49:218-228, 2001. (C) 2001 Wiley-Liss, Inc.
