Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds
Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds
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DOI：
10.1007/s11030-016-9691-x
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发表时间：
2016-11-01
影响因子：
3.8
通讯作者：
Li, Dianpeng
中科院分区：
文献类型：
--
作者：
Chen, Naiyuan;Duan, Wengui;Li, Dianpeng
为了寻找新的天然抗真菌药物，设计并合成了一系列具有1,3,4-噻二唑-噻唑烷酮片段的新型脱氢枞酸衍生物。初步生物测定结果表明，目标化合物3c、3f和3n在一定浓度下对玉米赤霉素具有良好的抑菌活性（抑菌率为91.3%），与市售抗真菌药物azoxystrobin（阳性对照）相当。
In an attempt to search for new natural products-based antifungal agents, a series of novel dehydroabietic acid derivatives bearing a 1,3,4-thiadiazole-thiazolidinone moiety were designed and synthesized. The primary bioassay used showed that at a concentration of , the target compounds 3c, 3f, and 3n exhibited excellent antifungal activity (91.3 % inhibition) against Gibberella zeae, which was equivalent to the commercial antifungal drug azoxystrobin (positive control).