PRIMARY SMALL-CELL CARCINOMA OF THE BLADDER - A REPORT OF 25 CASES
PRIMARY SMALL-CELL CARCINOMA OF THE BLADDER - A REPORT OF 25 CASES
复制标题
DOI：
10.1016/s0022-5347(01)67320-8
复制
发表时间：
1995-06-01
影响因子：
6.6
通讯作者：
JOHANSSON, SL
中科院分区：
文献类型：
--
作者：
HOLMANG, S;BORGHEDE, G;JOHANSSON, SL
原发性膀胱小细胞癌是一种罕见的疾病，据报道约有100例。在2年期间，在瑞典西部诊断的膀胱肿瘤中，小细胞癌的发生率为0.7%。我们描述了22例原发性小细胞癌患者，随访至死亡或至少6年。另外三个病例在尸检中被诊断出来。在接受局部治疗的18例T2M0至T4M0期癌症患者中，5例（28%）在中位10年（6至18年）观察后无疾病证据，13例在0.5至19个月（中位7.3个月）后死于疾病。两名转移性疾病患者接受了全身化疗，但在15个月内死亡。两名患者在诊断活检后不久死亡。我们的研究和文献回顾表明，原发性膀胱小细胞癌的侵袭性比肺小细胞癌小，一些患者可以通过经尿道膀胱切除术或部分或根治性膀胱切除术联合放疗治愈。
Primary small cell carcinoma of the bladder is a rare condition with approximately 100 cases reported to date. An incidence of 0.7% small cell carcinoma was found in a total series of bladder tumors diagnosed in Western Sweden during a 2-year period. We describe 22 patients with primary small cell carcinoma followed to death or for at least 6 years. Three additional cases were diagnosed at autopsy. Of 18 patients with stages T2M0 to T4M0 cancer treated with locoregional therapy 5 (28%) had no evidence of disease after a median observation of 10 years (range 6 to 18) and 13 died of disease after 0.5 to 19 months (median 7.3). Two patients with metastatic disease were treated with systemic chemotherapy but died within 15 months. Two patients died shortly after the diagnostic biopsy. Our study and a review of the literature indicate that primary small cell carcinoma of the bladder is less aggressive than its pulmonary counterpart and that some patients can be cured by transurethral resection, or partial or radical cystectomy combined with radiotherapy.