Involvement of histamine released from mast cells in acute radiation dermatitis in mice
Involvement of histamine released from mast cells in acute radiation dermatitis in mice
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DOI：
10.1254/jphs.sc0070127
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发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
Yamatodani, Atsushi
中科院分区：
文献类型：
--
作者：
Moriyasu, Saiko;Yamamoto, Kouichi;Yamatodani, Atsushi
组胺可能参与小鼠急性放射性皮炎的研究。40戈伊剂量的伽马辐照在用溶剂处理的C57 BL/6小鼠中诱导红斑和水肿。然而，在用氯苯那敏处理的C57 BL/6小鼠和WBB 6 F1-W/W-v小鼠中，未观察到红斑和水肿。在所有这些小鼠中，诱导脱毛和干燥脱屑，但贝他司汀显著降低了这些区域的程度。这些结果表明，γ射线诱导的红斑和水肿是由肥大细胞通过组胺H-1受体释放组胺引起的，脱毛是由其他炎症介质引起的。
A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/W-v mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H-1 receptor, and epilation was induced by other inflammatory mediators.