Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania
Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania
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DOI：
10.1016/s0035-9203(02)90349-4
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发表时间：
2002-11-01
影响因子：
2.2
通讯作者：
Sibley, CH
中科院分区：
文献类型：
--
作者：
Hastings, MD;Bates, SJ;Sibley, CH
2000年，我们使用一种敏感技术检测了来自坦桑尼亚Muheza疟疾患者的9株分离物，这些患者接受磺胺多辛-乙胺嘧啶（SP）治疗失败。三个分离株在与SP临床失败相关的164个氨基酸上低水平携带亮氨酸到异亮氨酸的变化。还观察到许多其他高抗性等位基因。
In 2000 we used a sensitive technique to examine 9 isolates from malaria patients in Muheza, Tanzania who had failed treatment with sulfadoxine-pyrimethamine (SP). Three isolates carried, at low levels, the leucine to isoleucine change at amino acid 164 that is associated with clinical failure of SP. Numerous other highly resistant alleles were also observed.