Methamphetamine and cannabis abuse in adolescence: a quasi-experimental study on specific and long-term neurocognitive effects.
Methamphetamine and cannabis abuse in adolescence: a quasi-experimental study on specific and long-term neurocognitive effects.
复制标题
DOI：
10.1136/bmjopen-2014-005833
复制
发表时间：
2015-01-30
期刊：
影响因子：
2.9
通讯作者：
Yurgelun-Todd D
中科院分区：
文献类型：
--
作者：
Cuzen NL;Koopowitz SM;Ferrett HL;Stein DJ;Yurgelun-Todd D
滥用甲基苯丙胺会影响大脑结构和功能。尽管甲基苯丙胺和大麻通常一起滥用，但很少有研究调查甲基苯丙胺与大麻一起滥用对神经认知的不同影响。此外，药物使用对发育中的青少年大脑的影响仍然知之甚少。我们比较了“单纯”滥用甲基苯丙胺的青少年、同时滥用甲基苯丙胺和大麻的青少年以及健康对照组在基线和随访时的神经认知功能。居住在大开普敦地区，年龄在13至18 岁之间的个人，采用准实验设计，被招募到只服用甲基苯丙胺组(仅服用冰毒；n=10)、甲基苯丙胺和大麻组(甲基苯丙胺和大麻；n=10)或健康对照组(n=20)。所有参与者都接受了全面的神经认知评估。药物使用变量和精神症状计数也被记录下来。部分仅服用蛋氨酸的参与者和对照组参与者完成了为期12个月的随访评估。虽然Meth-Cann组在基线时表现出广泛的神经认知缺陷，但在基线和随访时，这些缺陷仅限于Meth-Cann组的自我监测领域。与单独滥用甲基苯丙胺相比，滥用甲基苯丙胺与大麻滥用有关的神经认知障碍明显更多，而且这种缺陷可能是持久的。
Methamphetamine abuse affects brain structure and function. Although methamphetamine and cannabis are commonly abused together, few studies have investigated the differential neurocognitive consequences of methamphetamine abuse with or without cannabis. Furthermore, the effects of drug use on the developing adolescent brain remain poorly understood. We compared neurocognitive function between adolescents with ‘pure’ methamphetamine abuse, those with comorbid methamphetamine and cannabis abuse, and healthy controls at baseline and follow-up. Individuals residing in the greater Cape Town region, between the ages of 13 and 18 years, were recruited into either Methamphetamine only group (Meth-only; n=10), Methamphetamine and cannabis group (Meth-cann; n=10) or healthy control (n=20) groups using a quasi-experimental design. All participants underwent a comprehensive neurocognitive assessment. Substance-use variables and psychiatric symptom counts were also recorded. A portion of the Meth-only and control participants completed 12-month follow-up assessments. While the Meth-cann group demonstrated widespread neurocognitive deficits at baseline, these deficits were restricted to the self-monitoring domain in the Meth-only group at baseline and at follow-up. Methamphetamine abuse with cannabis abuse is associated with significantly more neurocognitive impairment than methamphetamine abuse alone, and such deficits may be enduring.