Protein and energy metabolism in type 1 diabetes
Protein and energy metabolism in type 1 diabetes
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DOI：
10.1016/j.clnu.2009.09.001
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发表时间：
2010-02-01
影响因子：
6.3
通讯作者：
Nair, K. Sreekumaran
中科院分区：
文献类型：
--
作者：
Hebert, Sadie L.;Nair, K. Sreekumaran
在胰岛素剥夺期间，I型糖尿病患者发生了深刻的代谢变化。这些包括基础能量消耗增加和线粒体功能降低。此外，蛋白质代谢在胰岛素剥夺期间受到显著影响。与蛋白质合成相比，全身蛋白质分解的增加更大，导致蛋白质净损失。在胰岛素缺乏期间，内脏床具有净蛋白质增加，其占全身蛋白质合成的总增加，而肌肉处于净分解代谢状态。(C)2009 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Profound metabolic changes occur in people with type I diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.