Subspecialization in the human posterior medial cortex.
Subspecialization in the human posterior medial cortex.
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DOI：
10.1016/j.neuroimage.2014.11.009
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发表时间：
2015-02-01
期刊：
影响因子：
5.7
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Bzdok D;Heeger A;Langner R;Laird AR;Fox PT;Palomero-Gallagher N;Vogt BA;Zilles K;Eickhoff SB
后内侧皮质（PMC）特别是知之甚少。它的神经活动变化与高度不同的心理过程有关。因此，我们研究PMC属性与数据驱动的探索性方法。首先，我们细分PMC的全脑共激活配置文件。其次，随后PMC区域的功能连接进行了比较任务约束的元分析共激活映射（MACM）和任务无约束的静息状态相关性（RSFC）。第三，PMC区域的功能描述的正向/反向功能推理。楔前叶簇主要与顶内沟、额眼区和右颞顶交界处相连;与注意力和运动任务相关。腹后扣带皮层（PCC）簇主要连接到腹内侧前额叶皮层和左下顶叶皮层（IPC）中部;与面部评价和语言任务相关。背侧PCC群集主要连接到背内侧前额叶皮质、前/后IPC、后中扣带回皮质和左背外侧前额叶皮质;与延迟折扣相关。压后皮质的一簇主要与前丘脑和海马相连。此外，所有PMC集群一致耦合到默认模式网络根据任务约束，而不是任务无约束的连接。因此，我们确定了PMC中的不同区域，并表征了它们的神经网络和功能意义。
The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC). Third, PMC regions were functionally described by forward/reverse functional inference. A precuneal cluster was mostly connected to the intraparietal sulcus, frontal eye fields, and right temporo-parietal junction; associated with attention and motor tasks. A ventral posterior cingulate cortex (PCC) cluster was mostly connected to the ventromedial prefrontal cortex and middle left inferior parietal cortex (IPC); associated with facial appraisal and language tasks. A dorsal PCC cluster was mostly connected to the dorsomedial prefrontal cortex, anterior/posterior IPC, posterior midcingulate cortex, and left dorsolateral prefrontal cortex; associated with delay discounting. A cluster in the retrosplenial cortex was mostly connected to the anterior thalamus and hippocampus. Furthermore, all PMC clusters were congruently coupled with the default mode network according to task-constrained but not task-unconstrained connectivity. We thus identified distinct regions in the PMC and characterized their neural networks and functional implications.