Differences in maternal gene expression in Cesarean section delivery compared with vaginal delivery.
Differences in maternal gene expression in Cesarean section delivery compared with vaginal delivery.
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DOI：
10.1038/s41598-020-74989-8
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发表时间：
2020-10-20
影响因子：
4.6
通讯作者：
Hourigan SK
中科院分区：
文献类型：
--
作者：
Kothiyal P;Schulkers K;Liu X;Hazrati S;Vilboux T;Gomez LM;Huddleston K;Wong WSW;Niederhuber JE;Conrads TP;Maxwell GL;Hourigan SK
剖宫产（CS）被认为是与慢性免疫疾病相关的共同环境危险因素。对不同分娩方式之间母体基因表达变化的研究可以增加我们对CS如何影响生命后期疾病模式的理解。通过对324名足月（≥37周）单胎母亲的横断面研究，我们评估了分娩方式与产后基因表达的关系。其中，181名母亲阴道分娩，143名母亲CS分娩（60名分娩，83名未分娩）。抗菌肽（AMP）在阴道分娩中与有或没有分娩的CS相比上调。肽酶抑制剂3 （PI3）是抗菌肽途径中的一种基因，已知参与抗菌和抗炎活性，与CS相比，有或没有分娩的阴道分娩增加了两倍（调整p值分别为1.57 × 10-11和3.70 × 10-13）。本研究评估了不同分娩方式下基因表达的差异，并提供了阴道分娩中抗菌肽上调的证据，与有或没有分娩的CS相比。需要进一步的探索来确定AMP的上调是否提供了对生命后期cs相关疾病的保护。
Cesarean section (CS) is recognized as being a shared environmental risk factor associated with chronic immune disease. A study of maternal gene expression changes between different delivery modes can add to our understanding of how CS contributes to disease patterns later in life. We evaluated the association of delivery mode with postpartum gene expression using a cross-sectional study of 324 mothers who delivered full-term (≥ 37 weeks) singletons. Of these, 181 mothers had a vaginal delivery and 143 had a CS delivery (60 with and 83 without labor). Antimicrobial peptides (AMP) were upregulated in vaginal delivery compared to CS with or without labor. Peptidase inhibitor 3 (PI3), a gene in the antimicrobial peptide pathway and known to be involved in antimicrobial and anti-inflammatory activities, showed a twofold increase in vaginal delivery compared to CS with or without labor (adjusted p-value 1.57 × 10–11 and 3.70 × 10–13, respectively). This study evaluates differences in gene expression by delivery mode and provides evidence of antimicrobial peptide upregulation in vaginal delivery compared to CS with or without labor. Further exploration is needed to determine if AMP upregulation provides protection against CS-associated diseases later in life.
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影响因子：
3.7
作者：
Darmasseelane K;Hyde MJ;Santhakumaran S;Gale C;Modi N
通讯作者：
Modi N
影响因子：
14.9
作者：
Frankish A;Diekhans M;Ferreira AM;Johnson R;Jungreis I;Loveland J;Mudge JM;Sisu C;Wright J;Armstrong J;Barnes I;Berry A;Bignell A;Carbonell Sala S;Chrast J;Cunningham F;Di Domenico T;Donaldson S;Fiddes IT;García Girón C;Gonzalez JM;Grego T;Hardy M;Hourlier T;Hunt T;Izuogu OG;Lagarde J;Martin FJ;Martínez L;Mohanan S;Muir P;Navarro FCP;Parker A;Pei B;Pozo F;Ruffier M;Schmitt BM;Stapleton E;Suner MM;Sycheva I;Uszczynska-Ratajczak B;Xu J;Yates A;Zerbino D;Zhang Y;Aken B;Choudhary JS;Gerstein M;Guigó R;Hubbard TJP;Kellis M;Paten B;Reymond A;Tress ML;Flicek P
通讯作者：
Flicek P
DOI：
10.1165/rcmb.2005-0405oc
发表时间：
2006-05-01
影响因子：
6.4
作者：
Roghanian, A;Williams, SE;Sallenave, JM
通讯作者：
Sallenave, JM
影响因子：
3
作者：
Dalman MR;Deeter A;Nimishakavi G;Duan ZH
通讯作者：
Duan ZH
影响因子：
14.2
作者：
Pistiner, Michael;Gold, Diane R.;Celedon, Juan C.
通讯作者：
Celedon, Juan C.