RISK-FACTORS THAT ATTENUATE THE FEMALE CORONARY-DISEASE ADVANTAGE
RISK-FACTORS THAT ATTENUATE THE FEMALE CORONARY-DISEASE ADVANTAGE
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DOI：
10.1001/archinte.155.1.57
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发表时间：
1995-01-09
影响因子：
--
通讯作者：
WILSON, PWF
中科院分区：
文献类型：
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作者：
KANNEL, WB;WILSON, PWF
目的：比较男性和女性在社区setting.Design结束设置冠心病的经验：前瞻性队列study.Patients：长期随访的人口为基础的样本5209名男性和女性。到中年时，妇女在心肌梗塞发病率方面比男子落后20年，但在老年人中，这一差距差距缩小，因为心血管疾病成为男女死亡的主要原因。更年期会使冠心病的风险迅速增加三倍，并大大削弱了女性相对于男性的优势。女性和男性有相同的冠心病主要危险因素，尽管女性的绝对风险较低。然而，高比率的总/高密度脂蛋白胆固醇水平的比率，左心室肥大，糖尿病往往消除女性的优势。结论：冠心病是一个不小的问题，在妇女。因此，妇女应采取有力的预防措施。有必要特别注意葡萄糖耐量和血脂水平，当高血压进展为左心室肥大时，需要有更大的紧迫感。
Objective: To compare the coronary disease experience of men and women in a community setting.Design end Setting: Prospective cohort study.Patients: Long-term follow-up of a population-based sample of 5209 men and women.Results: Women outlive men and experience fewer cardiovascular events. By middle age, women lag 20 years behind men in the incidence of myocardial infarction, but the gap closes in the elderly, when cardiovascular disease becomes the leading cause of death in women as well as in men. Menopause promptly escalates coronary disease risk threefold and greatly erodes the advantage over men. Women and men share the same major risk factors for coronary disease, although women experience a lower absolute risk. However, high ratios of total/high-density lipoprotein cholesterol level ratios, left ventricular hypertrophy, and diabetes tend to eliminate the female advantage.Conclusion: Coronary disease is not a minor problem in women. Consequently, women should take vigorous preventive measures. There is a need for particular attention to glucose tolerance and blood lipid levels and a greater sense of urgency when hypertension progresses to left ventricular hypertrophy.