Shape Transformations of Epithelial Shells
Shape Transformations of Epithelial Shells
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DOI：
10.1016/j.bpj.2016.03.009
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发表时间：
2016-04-12
影响因子：
3.4
通讯作者：
Shvartsman, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Misra, Mahim;Audoly, Basile;Shvartsman, Stanislav Y.
上皮细胞片层的机械性质的模式化常常预示着上皮细胞片层的调节性变形。在多个实验系统中研究了细胞特性模式与新出现的组织变形之间的联系，但对其一般原理仍然知之甚少。例如，通常不清楚是什么决定图案化片材将要弯曲的方向以及所得到的形状变换是不连续的还是平滑的。在这里，这些问题进行了探讨计算，使用顶点模型的上皮细胞组装从棱柱状细胞。响应于顶端细胞收缩性的环和斑块，模型上皮平滑地变形成类似于在胚胎和组织类器官中观察到的内陷或外翻形状。大多数观察到的效果可以捕获一个更简单的模型与多边形细胞，修改，包括apicobasal极性和自然曲率的上皮细胞的影响。我们的模型可以很容易地扩展到包括多个约束的影响，并用于描述广泛的形态发生过程。
Regulated deformations of epithelial sheets are frequently foreshadowed by patterning of their mechanical properties. The connection between patterns of cell properties and the emerging tissue deformations is studied in multiple experimental systems, but the general principles remain poorly understood. For instance, it is in general unclear what determines the direction in which the patterned sheet is going to bend and whether the resulting shape transformation will be discontinuous or smooth. Here these questions are explored computationally, using vertex models of epithelial shells assembled from prismlike cells. In response to rings and patches of apical cell contractility, model epithelia smoothly deform into invaginated or evaginated shapes similar to those observed in embryos and tissue organoids. Most of the observed effects can be captured by a simpler model with polygonal cells, modified to include the effects of the apicobasal polarity and natural curvature of epithelia. Our models can be readily extended to include the effects of multiple constraints and used to describe a wide range of morphogenetic processes.