11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma: A stereotactic image-histology comparison
11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma: A stereotactic image-histology comparison
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DOI：
10.1016/j.neuroimage.2009.11.024
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发表时间：
2010-02-15
期刊：
影响因子：
5.7
通讯作者：
Yoshimine, Toshiki
中科院分区：
文献类型：
--
作者：
Okita, Yoshiko;Kinoshita, Manabu;Yoshimine, Toshiki
c -11-蛋氨酸正电子发射断层扫描（c -11-蛋氨酸PET）提供准确的脑肿瘤检测。一些报告分析了c -11-蛋氨酸摄取与Ki-67指数或微血管密度的非立体定向相关性，并表明c -11-蛋氨酸摄取反映了胶质瘤的增殖潜力和血管生成能力。由于胶质瘤具有异质性的组织结构，非立体定向比较组织学和c -11-蛋氨酸PET图像可能不准确。本研究利用立体定向活检获得的组织学标本，分析c -11-蛋氨酸摄取与细胞或微血管密度的相关性，并将c -11-蛋氨酸PET图像与组织学标本进行精确的局部比较。c -11-蛋氨酸正电子发射断层扫描的肿瘤/正常组织（T/N）比值与细胞密度（R = 0.747, p = 0.000042）和Ki-67指数（R = 0.675, p = 0.00041）的相关性优于微血管密度（R = 0.467）。P = 0.025)，使用立体定向图像进行组织学比较。此外，多元线性回归分析显示细胞密度是预测c -11-蛋氨酸水平的关键决定因素，而微血管密度不是。这些结果表明，在胶质瘤组织中，细胞密度比微血管密度对c -11-蛋氨酸摄取的贡献更大，之前报道的胶质瘤患者c -11-蛋氨酸摄取与微血管密度的相关性需要重新评估。(C) 2009爱思唯尔公司版权所有。
C-11-methionine positron emission tomography (C-11-methionine PET) provides accurate detection of brain tumors. Several reports have analyzed the correlation between uptake of C-11-methionine and Ki-67 index or microvessel density non-stereotactically and Suggested that C-11-methionine uptake reflects both proliferation potential and angiogenic capability in gliomas. As gliomas possess heterogeneous histological architecture, non-stereotactic comparison of the histology and C-11-methionine PET image may not be accurate. in the present study, the correlation between C-11-methionine uptake and cell or microvessel density was analyzed using histological specimens obtained by stereotactic biopsy, and an exact local comparison of C-11-methionine PET image and histological specimens was conducted. The tumor/normal tissue (T/N) ratio of C-11-methionine positron emission tomography was found to correlate better with cell density (R = 0.747, p = 0.000042) and Ki-67 index (R = 0.675, p = 0.00041) than with microvessel density (R = 0.467. p = 0.025) in a histological comparison using a stereotactic image. Furthermore, multiple linear regression analysis revealed that cell density was the key determinant for predicting C-11-methionine level while microvessel density was not. These results suggest that cell density contributes more to C-11-methionine uptake than microvessel density in glioma tissues and that the previously reported correlation of C-11-methionine uptake and microvessel density in glioma patients requires reevaluation. (C) 2009 Elsevier Inc. All rights reserved.