ULTRASONIC MEASUREMENT OF THE ELASTIC-MODULUS OF THE COMMON CAROTID-ARTERY - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
ULTRASONIC MEASUREMENT OF THE ELASTIC-MODULUS OF THE COMMON CAROTID-ARTERY - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
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DOI：
10.1161/01.str.23.7.952
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发表时间：
1992-07-01
期刊：
影响因子：
8.3
通讯作者：
BURKE, GL
中科院分区：
文献类型：
--
作者：
RILEY, WA;BARNES, RW;BURKE, GL
Background and Purpose: The Atherosclerosis Risk in Communities Study is a prospective investigation of the etiology and natural history of atherosclerosis and the etiology of clinical disease in four US communities.Methods: Noninvasive ultrasonic methods were used to determine mean wall thickness (WT), radius (R), and circumferential arterial strain (CAS) in the left common carotid artery of 3,321 white male and female study participants between the ages of 45 and 64 years. The mean and standard deviation of Young's elastic modulus (Y) in 5-year age groups were determined for each sex by combining the ultrasonic data with concurrent noninvasive measurements of pulse pressure (PP) in the right brachial artery using the equation Y=(R/WT) x (PP/CAS).Results: Significant (p=0.0001) age group differences in Y were observed in both sexes, with the mean value increasing from 701 kPa in women and 771 kPa in men in the 45-49-year-old age group to 965 and 983 kPa, respectively, in the 60-64-year-old age group. Significant (p=0.0001) age group differences were also observed for WT, the WT/R ratio, PP, CAS, and the PP/CAS ratio in both sexes. A sex difference in Y was detected (male>female, p=0.0006) only in the 45-49-year-old age group. Significant (p
