Higher Reported Saturated Fat and Refined Sugar Intake Is Associated With Reduced Hippocampal-Dependent Memory and Sensitivity to Interoceptive Signals
Higher Reported Saturated Fat and Refined Sugar Intake Is Associated With Reduced Hippocampal-Dependent Memory and Sensitivity to Interoceptive Signals
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DOI：
10.1037/a0025998
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发表时间：
2011-12-01
影响因子：
1.9
通讯作者：
Stevenson, Richard J.
中科院分区：
文献类型：
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作者：
Francis, Heather M.;Stevenson, Richard J.
能量摄入的调节部分取决于先前食物摄入的记忆和饥饿和饱腹感的内部信号。这些功能都是由海马体介导的，海马体是一种大脑结构，动物研究表明，在维持高脂肪和精制糖（HFS）饮食后会受损。研究1，采用横断面设计，揭示了自我报告的HFS饮食与海马敏感记忆任务的表现较差，但没有其他神经心理控制措施。研究2在选择不同HFS摄入量的两组中复制了这一发现，另外还表明这种影响是特定于海马功能的，并没有扩展到前额叶皮质功能的测量。此外，在一项基于实验室的食物摄入测试中，富含HFS的饮食组在回忆他们以前吃过的食物时不太准确，并且相对于摄入较少HFS的饮食组，对饥饿和饱腹感的内部信号的敏感性降低。总之，这些发现揭示了人类参与者中HFS消耗与海马功能较差之间的关联，与基于动物的研究结果一致。此外，我们的研究结果表明，这可能与通过对先前食物摄入的不准确跟踪以及对饥饿和饱足信号的敏感性降低而损害能量摄入的调节有关。
Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using a cross-sectional design, revealed that self-reported HFS diet was associated with poorer performance on hippocampal sensitive memory tasks but not other neuropsychological control measures. Study 2 replicated this finding in two groups selected to differ in HFS intake, additionally showing that this effect is specific to hippocampal functioning and does not extend to measures of prefrontal cortex function. Furthermore, in a laboratory-based test of food intake, the HFS rich diet groups were less accurate in recalling what they had previously eaten and evidenced reduced sensitivity to internal signals of hunger and satiety, relative to a group consuming less HFS rich diets. Together, these findings reveal an association between HFS consumption and poorer hippocampal function in human participants, consistent with findings from animal-based studies. Moreover, our results suggest that this may be related to impaired regulation of energy intake via less accurate tracking of prior food intake and reduced sensitivity to hunger and satiety signals.