EFFICIENCY OF BALANCED TREATMENT ALLOCATION FOR SURVIVAL ANALYSIS
EFFICIENCY OF BALANCED TREATMENT ALLOCATION FOR SURVIVAL ANALYSIS
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DOI：
10.2307/2531593
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发表时间：
1988-09-01
期刊：
影响因子：
1.9
通讯作者：
HARRINGTON, DP
中科院分区：
文献类型：
--
作者：
KALISH, LA;HARRINGTON, DP
We assess the efficiency of balanced treatment allocation methods in clinical trials for comparing treatments with respect to survival. We compare optimal designs for each of three standard survival analysis techniques (maximum partial likelihood estimation, log-rank test, exponential regression) with balanced designs, over a range of hypothetical trials. Although balanced designs are not optimal, we find them to be very efficient. In view of the high efficiency demonstrated in this and in a previous paper (Begg and Kalish, 1984, Biometrics 40, 409-420), and practical difficulties in implementing an optimal design, we recommend the use of balanced allocation methods in practice.
