Gastric blood flow in endotoxin-induced stress ulcer.
Gastric blood flow in endotoxin-induced stress ulcer.
复制标题
内毒素引起的应激性溃疡中的胃血流。
DOI：
10.1001/archsurg.1973.01350140049015
复制
发表时间：
1973
影响因子：
--
通讯作者：
B. Eiseman
中科院分区：
文献类型：
--
作者：
R. Richardson;L. Norton;J. Sales;B. Eiseman
用放射性微球在猪应激性溃疡模型上观察了内毒素休克对胃血流分布的影响。10头仔猪静脉注射大肠杆菌内毒素休克，并与6个对照组进行比较。通过测定2厘米见方的胃切片，计算休克前后的血流量。胃血流的分布进行了图形分析和缺血区溃疡面积进行了比较。内毒素引起胃血流量的重新分布，但不平行于心输出量的变化。缺血是最大的身体每克流量下降62.2%，应激性溃疡只在该地区的所有休克动物。对照组中没有胃血流量超过心输出量的溃疡。内毒素引起的选择性局部胃缺血与出血后的弥漫性斑片状血流不同。
The effect of endotoxin shock on the distribution of gastric blood flow was measured with radioactive microspheres in a swine stress ulcer model. Ten piglets were shocked with intravenously administered Escherichia coli endotoxin and compared with six controls. Blood flow was calculated before and after shock by assaying 2-cm square sections of stomach. Distribution of gastric blood flow was analyzed graphically and ischemic regions were compared to ulcerated areas. Endotoxin caused a redistribution of gastric blood flow which did not parallel cardiac output change. Ischemia was maximum in the corpus where flow per gram decreased 62.2%, and stress ulcers developed only in this region in all shocked animals. There were no ulcers in controls where gastric blood flow paralleled cardiac output. Endotoxin caused a selective regional gastric ischemia unlike the diffuse, patchy flow seen following hemorrhage.